Keavney Lab
Understanding the links between genetics and cardiovascular disease
Welcome to Keavney Lab Research Group website.
We are a research group led by Professor Bernard Keavney and supported by the British Heart Foundation. Our focus is on the genetics of cardiovascular disease, with particular emphasis on congenital heart disease and the processes involved in heart development. We are based at the University of Manchester and collaborate with national and international institutions. Explore our website to learn more about our work and team.
Research Interests
Our research group's interests lie in understanding the genetics of cardiovascular disease and its underlying mechanisms. We employ advanced molecular and cellular techniques, as well as genetic and genomic approaches, to investigate the molecular pathways that regulate heart development and cause heart disease. Our ultimate goal is to identify new therapeutic targets for congenital heart disease and other cardiovascular conditions. We collaborate with clinical and academic partners to translate our findings into clinical practice and improve patient outcomes.
1: Spracklen TF, Keavney B, Laing N, Ntusi N, Shaboodien G. Modern genomic techniques in the identification of genetic causes of cardiomyopathy. Heart. 2022 Feb 9:heartjnl-2021-320424. doi: 10.1136/heartjnl-2021-320424. Epub ahead of print. PMID: 35140110
2: Williams SG, Byrne DJF, Keavney BD. Rare GATA6 variants associated with risk of congenital heart disease phenotypes in 200,000 UK Biobank exomes. J Hum Genet. 2022 Feb;67(2):123-125. doi: 10.1038/s10038-021-00976-0. Epub 2021 Sep 7. PMID: 34493817; PMCID: PMC8786659.
3: Liu Y, Williams SG, Jones HR, Keavney B, Choy MK. A novel RNA-mediated mechanism causing down-regulation of insulating promoter interactions in human embryonic stem cells. Sci Rep. 2021 Dec 1;11(1):23233. doi: 10.1038/s41598-021-02373-1. PMID: 34853328; PMCID: PMC8636647.