Recent Publications

1: Spracklen TF, Keavney B, Laing N, Ntusi N, Shaboodien G. Modern genomic techniques in the identification of genetic causes of cardiomyopathy. Heart. 2022 Feb 9:heartjnl-2021-320424. doi: 10.1136/heartjnl-2021-320424. Epub ahead of print. PMID: 35140110.
 

2: Williams SG, Byrne DJF, Keavney BD. Rare GATA6 variants associated with risk of congenital heart disease phenotypes in 200,000 UK Biobank exomes. J Hum Genet. 2022 Feb;67(2):123-125. doi: 10.1038/s10038-021-00976-0. Epub 2021 Sep 7. PMID: 34493817; PMCID: PMC8786659.
 

3: Škorić-Milosavljević D, Tadros R, Bosada FM, Tessadori F, van Weerd JH, Woudstra OI, Tjong FVY, Lahrouchi N, Bajolle F, Cordell HJ, Agopian AJ, Blue GM, Barge-Schaapveld DQCM, Gewillig M, Preuss C, Lodder EM, Barnett P, Ilgun A, Beekman L, van Duijvenboden K, Bokenkamp R, Müller-Nurasyid M; KORA-Study Group, Vliegen HW, Konings TC, van Melle JP, van Dijk APJ, van Kimmenade RRJ, Roos- Hesselink JW, Sieswerda GT, Meijboom F, Abdul-Khaliq H, Berger F, Dittrich S, Hitz MP, Moosmann J, Riede FT, Schubert S, Galan P, Lathrop M, Munter HM, Al- Chalabi A, Shaw CE, Shaw PJ, Morrison KE, Veldink JH, van den Berg LH, Evans S, Nobrega MA, Aneas I, Radivojkov-Blagojević M, Meitinger T, Oechslin E, Mondal T, Bergin L, Smythe JF, Altamirano-Diaz L, Lougheed J, Bouma BJ, Chaix MA, Kline J, Bassett AS, Andelfinger G, van der Palen RLF, Bouvagnet P, Clur SB, Breckpot J, Kerstjens-Frederikse WS, Winlaw DS, Bauer UMM, Mital S, Goldmuntz E, Keavney B, Bonnet D, Mulder BJ, Tanck MWT, Bakkers J, Christoffels VM, Boogerd CJ, Postma AV, Bezzina CR. Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries. Circ Res. 2022 Jan 21;130(2):166-180. doi: 10.1161/CIRCRESAHA.120.317107. Epub 2021 Dec 10. PMID: 34886679; PMCID: PMC8768504.
 

4: Liu Y, Williams SG, Jones HR, Keavney B, Choy MK. A novel RNA-mediated mechanism causing down-regulation of insulating promoter interactions in human embryonic stem cells. Sci Rep. 2021 Dec 1;11(1):23233. doi: 10.1038/s41598-021-02373-1. PMID: 34853328; PMCID: PMC8636647.
 

5: Aldersley T, Lawrenson J, Human P, Shaboodien G, Cupido B, Comitis G, De Decker R, Fourie B, Swanson L, Joachim A, Magadla P, Ngoepe M, Swanson L, Revell A, Ramesar R, Brooks A, Saacks N, De Koning B, Sliwa K, Anthony J, Osman A, Keavney B, Zühlke L. PROTEA, A Southern African Multicenter Congenital Heart Disease Registry and Biorepository: Rationale, Design, and Initial Results. Front Pediatr. 2021 Oct 20;9:763060. doi: 10.3389/fped.2021.763060. PMID: 34746065; PMCID: PMC8564377.
 

6: Škorić-Milosavljević D, Lahrouchi N, Bosada FM, Dombrowsky G, Williams SG, Lesurf R, Tjong FVY, Walsh R, El Bouchikhi I, Breckpot J, Audain E, Ilgun A, Beekman L, Ratbi I, Strong A, Muenke M, Heide S, Muir AM, Hababa M, Cross L, Zhou D, Pastinen T; German Competence Network for Congenital Heart Defects, Zackai E, Atmani S, Ouldim K, Adadi N, Steindl K, Rauch A, Brook D, Wilsdon A, Kuipers I, Blom NA, Mulder BJ, Mefford HC, Keren B, Joset P, Kruszka P, Thiffault I, Sheppard SE, Roberts A, Lodder EM, Keavney BD, Clur SB, Mital S, Hitz MP, Christoffels VM, Postma AV, Bezzina CR. Rare variants in KDR, encoding VEGF Receptor 2, are associated with tetralogy of Fallot. Genet Med. 2021 Oct;23(10):1952-1960. doi: 10.1038/s41436-021-01212-y. Epub 2021 Jun 10. Erratum in: Genet Med. 2021 Sep 14;: PMID: 34113005; PMCID: PMC8486653.
 

7: Machipisa T, Chong M, Muhamed B, Chishala C, Shaboodien G, Pandie S, de Vries J, Laing N, Joachim A, Daniels R, Ntsekhe M, Hugo-Hamman CT, Gitura B, Ogendo S, Lwabi P, Okello E, Damasceno A, Novela C, Mocumbi AO, Madeira G, Musuku J, Mtaja A, ElSayed A, Elhassan HHM, Bode-Thomas F, Okeahialam BN, Zühlke LJ, Mulder N, Ramesar R, Lesosky M, Parks T, Cordell HJ, Keavney B, Engel ME, Paré G. Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals: Findings From the RHDGen Study. JAMA Cardiol. 2021 Sep 1;6(9):1000-1011. doi: 10.1001/jamacardio.2021.1627. PMID: 34106200; PMCID: PMC8190704.
 

8: Reuter MS, Chaturvedi RR, Jobling RK, Pellecchia G, Hamdan O, Sung WWL, Nalpathamkalam T, Attaluri P, Silversides CK, Wald RM, Marshall CR, Williams SG, Keavney BD, Thiruvahindrapuram B, Scherer SW, Bassett AS. Clinical Genetic Risk Variants Inform a Functional Protein Interaction Network for Tetralogy of Fallot. Circ Genom Precis Med. 2021 Aug;14(4):e003410. doi: 10.1161/CIRCGEN.121.003410. Epub 2021 Jul 30. PMID: 34328347; PMCID: PMC8373675.
 

9: Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney PE, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire S, Coselli JS, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. PLoS Genet. 2021 Jul 29;17(7):e1009679. doi: 10.1371/journal.pgen.1009679. Erratum in: PLoS Genet. 2021 Sep 21;17(9):e1009809. PMID: 34324492; PMCID: PMC8354477.
 

10: Monaghan RM, Page DJ, Ostergaard P, Keavney BD. The physiological and pathological functions of VEGFR3 in cardiac and lymphatic development and related diseases. Cardiovasc Res. 2021 Jul 7;117(8):1877-1890. doi: 10.1093/cvr/cvaa291. PMID: 33067626; PMCID: PMC8262640.
 

11: Kraus SM, Shaboodien G, Francis V, Laing N, Cirota J, Chin A, Pandie S, Lawrenson J, Comitis GAM, Fourie B, Zühlke L, Wonkam A, Wainwright H, Damasceno A, Mocumbi AO, Pepeta L, Moeketsi K, Thomas BM, Thomas K, Makotoko M, Brown S, Ntsekhe M, Sliwa K, Badri M, Gumedze F, Cordell HJ, Keavney B, Ferreira V, Mahmod M, Cooper LT, Yacoub M, Neubauer S, Watkins H, Mayosi BM, Ntusi NAB; IMHOTEP Investigators. Rationale and design of the African Cardiomyopathy and Myocarditis Registry Program: The IMHOTEP study. Int J Cardiol. 2021 Jun 15;333:119-126. doi: 10.1016/j.ijcard.2021.02.026. Epub 2021 Feb 16. PMID: 33607192.
 

12: McGurk KA, Keavney BD, Nicolaou A. Circulating ceramides as biomarkers of cardiovascular disease: Evidence from phenotypic and genomic studies. Atherosclerosis. 2021 Jun;327:18-30. doi: 10.1016/j.atherosclerosis.2021.04.021. Epub 2021 May 7.F PMID: 34004484.
 

13: Eales JM, Jiang X, Xu X, Saluja S, Akbarov A, Cano-Gamez E, McNulty MT, Finan C, Guo H, Wystrychowski W, Szulinska M, Thomas HB, Pramanik S, Chopade S, Prestes PR, Wise I, Evangelou E, Salehi M, Shakanti Y, Ekholm M, Denniff M, Nazgiewicz A, Eichinger F, Godfrey B, Antczak A, Glyda M, Król R, Eyre S, Brown J, Berzuini C, Bowes J, Caulfield M, Zukowska-Szczechowska E, Zywiec J, Bogdanski P, Kretzler M, Woolf AS, Talavera D, Keavney B, Maffia P, Guzik TJ, O'Keefe RT, Trynka G, Samani NJ, Hingorani A, Sampson MG, Morris AP, Charchar FJ, Tomaszewski M. Uncovering genetic mechanisms of hypertension through multi- omic analysis of the kidney. Nat Genet. 2021 May;53(5):630-637. doi: 10.1038/s41588-021-00835-w. Epub 2021 May 6. PMID: 33958779.
 

14: McGurk KA, Williams SG, Guo H, Watkins H, Farrall M, Cordell HJ, Nicolaou A, Keavney BD. Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome. Hum Mol Genet. 2021 Apr 30;30(6):500-513. doi: 10.1093/hmg/ddab002. PMID: 33437986; PMCID: PMC8101358.
 

15: Gurumurthy CB, O'Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo- Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb K, Eudy JD, Gan L, Gao J, Gonzales A, Guntur A, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majeweska L, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford A, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G. Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation". Genome Biol. 2021 Apr 7;22(1):99. doi: 10.1186/s13059-021-02320-3. PMID: 33827648; PMCID: PMC8025318.
 

16: Spracklen TF, Kasher PR, Kraus S, Botha TL, Page DJ, Kamuli S, Booi Z, Chin A, Laing N, Keavney BD, Ntusi NAB, Shaboodien G. Identification of a POLG Variant in a Family With Arrhythmogenic Cardiomyopathy and Left Ventricular Fibrosis. Circ Genom Precis Med. 2021 Feb;14(1):e003138. doi: 10.1161/CIRCGEN.120.003138. Epub 2020 Dec 4. PMID: 33276707.
 

17: Lahm H, Jia M, Dreßen M, Wirth F, Puluca N, Gilsbach R, Keavney BD, Cleuziou J, Beck N, Bondareva O, Dzilic E, Burri M, König KC, Ziegelmüller JA, Abou-Ajram C, Neb I, Zhang Z, Doppler SA, Mastantuono E, Lichtner P, Eckstein G, Hörer J, Ewert P, Priest JR, Hein L, Lange R, Meitinger T, Cordell HJ, Müller-Myhsok B, Krane M. Congenital heart disease risk loci identified by genome-wide association study in European patients. J Clin Invest. 2021 Jan 19;131(2):e141837. doi: 10.1172/JCI141837. PMID: 33201861; PMCID: PMC7810487.
 

18: Malhotra A, Oxborough D, Rao P, Finocchiaro G, Dhutia H, Prasad V, Miller C, Keavney B, Papadakis M, Sharma S. Defining the Normal Spectrum of Electrocardiographic and Left Ventricular Adaptations in Mixed-Race Male Adolescent Soccer Players. Circulation. 2021 Jan 5;143(1):94-96. doi: 10.1161/CIRCULATIONAHA.120.049740. Epub 2020 Dec 30. PMID: 33378235.
 

19: Jiang X, Eales JM, Scannali D, Nazgiewicz A, Prestes P, Maier M, Denniff M, Xu X, Saluja S, Cano-Gamez E, Wystrychowski W, Szulinska M, Antczak A, Byars S, Skrypnik D, Glyda M, Król R, Zywiec J, Zukowska-Szczechowska E, Burrell LM, Woolf AS, Greenstein A, Bogdanski P, Keavney B, Morris AP, Heagerty A, Williams B, Harrap SB, Trynka G, Samani NJ, Guzik TJ, Charchar FJ, Tomaszewski M. Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney. Eur Heart J. 2020 Dec 21;41(48):4580-4588. doi: 10.1093/eurheartj/ehaa794. PMID: 33206176; PMCID: PMC7665509.
 

20: Córdova-Palomera A, Tcheandjieu C, Fries JA, Varma P, Chen VS, Fiterau M, Xiao K, Tejeda H, Keavney BD, Cordell HJ, Tanigawa Y, Venkataraman G, Rivas MA, Ré C, Ashley E, Priest JR. Cardiac Imaging of Aortic Valve Area From 34 287 UK Biobank Participants Reveals Novel Genetic Associations and Shared Genetic Comorbidity With Multiple Disease Phenotypes. Circ Genom Precis Med. 2020 Dec;13(6):e003014. doi: 10.1161/CIRCGEN.120.003014. Epub 2020 Oct 30. PMID: 33125279.
 

21: Liu Y, Chen S, Zühlke L, Babu-Narayan SV, Black GC, Choy MK, Li N, Keavney BD. Global prevalence of congenital heart disease in school-age children: a meta-analysis and systematic review. BMC Cardiovasc Disord. 2020 Nov 19;20(1):488. doi: 10.1186/s12872-020-01781-x. PMID: 33213369; PMCID: PMC7678306.
 

22: Trevino CE, Holleman AM, Corbitt H, Maslen CL, Rosser TC, Cutler DJ, Johnston HR, Rambo-Martin BL, Oberoi J, Dooley KJ, Capone GT, Reeves RH, Cordell HJ, Keavney BD, Agopian AJ, Goldmuntz E, Gruber PJ, O'Brien JE Jr, Bittel DC, Wadhwa L, Cua CL, Moskowitz IP, Mulle JG, Epstein MP, Sherman SL, Zwick ME. Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome. Sci Rep. 2020 Oct 22;10(1):18051. doi: 10.1038/s41598-020-74650-4. Erratum in: Sci Rep. 2021 Jul 20;11(1):15164. PMID: 33093519; PMCID: PMC7582922.
 

23: Owen B, Nasar AMA, Harwood ARG, Hewitt S, Bojdo N, Keavney BD, Rogers BD, Revell A. Vector-based discrete element method for solid elastic materials. Computer Physics Communications. 2020 Sep; 254:107353. doi: 10.1016/j.cpc.2020.107353.
 

24: McGurk KA, Owen B, Watson WD, Nethononda RM, Cordell HJ, Farrall M, Rider OJ, Watkins H, Revell A, Keavney BD. Heritability of haemodynamics in the ascending aorta. Sci Rep. 2020 Sep 1;10(1):14356. doi: 10.1038/s41598-020-71354-7. PMID: 32873833; PMCID: PMC7463029.
 

25: Williams SG, Nakev A, Guo H, Frain S, Tenin G, Liakhovitskaia A, Saha P, Priest JR, Hentges KE, Keavney BD. Association of congenital cardiovascular malformation and neuropsychiatric phenotypes with 15q11.2 (BP1-BP2) deletion in the UK Biobank. Eur J Hum Genet. 2020 Sep;28(9):1265-1273. doi: 10.1038/s41431-020-0626-8. Epub 2020 Apr 23. PMID: 32327713; PMCID: PMC7608352.
 

26: Swanson L, Owen B, Keshmiri A, Deyranlou A, Aldersley T, Lawrenson J, Human P, De Decker R, Fourie B, Comitis G, Engel ME, Keavney B, Zühlke L, Ngoepe M, Revell A. A Patient-Specific CFD Pipeline Using Doppler Echocardiography for Application in Coarctation of the Aorta in a Limited Resource Clinical Context. Front Bioeng Biotechnol. 2020 Jun 3;8:409. doi: 10.3389/fbioe.2020.00409. PMID: 32582648; PMCID: PMC7283385.
 

27: McGurk KA, Dagliati A, Chiasserini D, Lee D, Plant D, Baricevic-Jones I, Kelsall J, Eineman R, Reed R, Geary B, Unwin RD, Nicolaou A, Keavney BD, Barton A, Whetton AD, Geifman N. The use of missing values in proteomic data- independent acquisition mass spectrometry to enable disease activity discrimination. Bioinformatics. 2020 Apr 1;36(7):2217-2223. doi: 10.1093/bioinformatics/btz898. PMID: 31790148; PMCID: PMC7141869.
 

28: Martin-Ruiz C, Hoffmann J, Shmeleva E, Zglinicki TV, Richardson G, Draganova L, Redgrave R, Collerton J, Arthur H, Keavney B, Spyridopoulos I. CMV- independent increase in CD27-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians. NPJ Aging Mech Dis. 2020 Jan 21;6:3. doi: 10.1038/s41514-019-0041-y. PMID: 31993214; PMCID: PMC6972903.
 

29: Keavney BD, McGurk KA. The Open Science of Atrial Fibrillation. Circ Res. 2020 Jan 17;126(2):210-211. doi: 10.1161/CIRCRESAHA.119.316357. Epub 2020 Jan 16. PMID: 31944917.
 

30: Eales JM, Maan AA, Xu X, Michoel T, Hallast P, Batini C, Zadik D, Prestes PR, Molina E, Denniff M, Schroeder J, Bjorkegren JLM, Thompson J, Maffia P, Guzik TJ, Keavney B, Jobling MA, Samani NJ, Charchar FJ, Tomaszewski M. Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis. Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2386-2401. doi: 10.1161/ATVBAHA.119.312405. Epub 2019 Sep 5. PMID: 31644355; PMCID: PMC6818981.
 

31: Anderson SG, Shoaib A, Myint PK, Cleland JG, Hardman SM, McDonagh TA, Dargie H, Keavney B, Garratt CJ, Mamas MA. Does rhythm matter in acute heart failure? An insight from the British Society for Heart Failure National Audit. Clin Res Cardiol. 2019 Nov;108(11):1276-1286. doi: 10.1007/s00392-019-01463-5. Epub 2019 Apr 8. PMID: 30963233; PMCID: PMC6805810.
 

32: Fotiou E, Williams S, Martin-Geary A, Robertson DL, Tenin G, Hentges KE, Keavney B. Integration of Large-Scale Genomic Data Sources With Evolutionary History Reveals Novel Genetic Loci for Congenital Heart Disease. Circ Genom Precis Med. 2019 Oct;12(10):442-451. doi: 10.1161/CIRCGEN.119.002694. Epub 2019 Oct 15. PMID: 31613678; PMCID: PMC6798745.
 

33: Nethononda RM, McGurk KA, Whitworth P, Francis J, Mamasoula C, Cordell HJ, Neubauer S, Keavney BD, Mayosi BM, Farrall M, Watkins H. Marked variation in heritability estimates of left ventricular mass depending on modality of measurement. Sci Rep. 2019 Sep 19;9(1):13556. doi: 10.1038/s41598-019-49961-w. PMID: 31537879; PMCID: PMC6753112.
 

34: Cacciottolo TM, Perikari A, van der Klaauw A, Henning E, Stadler LKJ, Keogh J, Farooqi IS, Tenin G, Keavney B, Ryan E, Budd R, Bewley M, Coelho P, Rumsey W, Sanchez Y, McCafferty J, Dockrell D, Walmsley S, Whyte M, Liu Y, Choy MK, Tenin G, Abraham S, Black G, Keavney B, Ford T, Stanley B, Good R, Rocchiccioli P, McEntegart M, Watkins S, Eteiba H, Shaukat A, Lindsay M, Robertson K, Hood S, McGeoch R, McDade R, Sidik N, McCartney P, Corcoran D, Collison D, Rush C, McConnachie A, Touyz R, Oldroyd K, Berry C, Gazdagh G, Diver L, Marshall J, McGowan R, Ahmed F; DDD Study, Tobias E, Curtis E, Parsons C, Maslin K, D'Angelo S, Moon R, Crozier S, Gossiel F, Bishop N, Kennedy S, Papageorghiou A, Fraser R, Gandhi S, Prentice A, Inskip H, Godfrey K, Schoenmakers I, Javaid MK, Eastell R, Cooper C, Harvey N, Watt ER, Howden A, Mirchandani A, Coelho P, Hukelmann JL, Sadiku P, Plant TM, Cantrell DA, Whyte MKB, Walmsley SR, Mordi I, Forteath C, Wong A, Mohan M, Palmer C, Doney A, Rena G, Lang C, Gray EH, Azarian S, Riva A, Edwards H, McPhail MJW, Williams R, Chokshi S, Patel VC, Edwards LA, Page D, Miossec M, Williams S, Monaghan R, Fotiou E; CHANGE Study Collaborators, CheartED Study Collaborators, Santibanez-Koref M, Keavney B, Badat M, Mettananda S, Hua P, Schwessinger R, Hughes J, Higgs D, Davies J. Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland. QJM. 2019 Sep 1;112(9):724-729. doi: 10.1093/qjmed/hcz175. PMID: 31505685.
 

35: Testori A, Lasorsa VA, Cimmino F, Cantalupo S, Cardinale A, Avitabile M, Limongelli G, Russo MG, Diskin S, Maris J, Devoto M, Keavney B, Cordell HJ, Iolascon A, Capasso M. Exploring Shared Susceptibility between Two Neural Crest Cells Originating Conditions: Neuroblastoma and Congenital Heart Disease. Genes (Basel). 2019 Aug 30;10(9):663. doi: 10.3390/genes10090663. PMID: 31480262; PMCID: PMC6771154.
 

36: Gurumurthy CB, O'Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo- Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G. Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome Biol. 2019 Aug 26;20(1):171. doi: 10.1186/s13059-019-1776-2. PMID: 31446895; PMCID: PMC6709553.
 

37: Liu Y, Chen S, Zühlke L, Black GC, Choy MK, Li N, Keavney BD. Global birth prevalence of congenital heart defects 1970-2017: updated systematic review and meta-analysis of 260 studies. Int J Epidemiol. 2019 Apr 1;48(2):455-463. doi: 10.1093/ije/dyz009. PMID: 30783674; PMCID: PMC6469300.
 

38: Keavney B. Chicken or Egg in the UK Biobank? Circ Res. 2019 Mar 15;124(6):830-831. doi: 10.1161/CIRCRESAHA.119.314756. PMID: 30870123; PMCID: PMC6420132.
 

39: Page DJ, Miossec MJ, Williams SG, Monaghan RM, Fotiou E, Cordell HJ, Sutcliffe L, Topf A, Bourgey M, Bourque G, Eveleigh R, Dunwoodie SL, Winlaw DS, Bhattacharya S, Breckpot J, Devriendt K, Gewillig M, Brook JD, Setchfield KJ, Bu'Lock FA, O'Sullivan J, Stuart G, Bezzina CR, Mulder BJM, Postma AV, Bentham JR, Baron M, Bhaskar SS, Black GC, Newman WG, Hentges KE, Lathrop GM, Santibanez-Koref M, Keavney BD. Whole Exome Sequencing Reveals the Major Genetic Contributors to Nonsyndromic Tetralogy of Fallot. Circ Res. 2019 Feb 15;124(4):553-563. doi: 10.1161/CIRCRESAHA.118.313250. PMID: 30582441; PMCID: PMC6377791.
 

40: Inouye M, Abraham G, Nelson CP, Wood AM, Sweeting MJ, Dudbridge F, Lai FY, Kaptoge S, Brozynska M, Wang T, Ye S, Webb TR, Rutter MK, Tzoulaki I, Patel RS, Loos RJF, Keavney B, Hemingway H, Thompson J, Watkins H, Deloukas P, Di Angelantonio E, Butterworth AS, Danesh J, Samani NJ; UK Biobank CardioMetabolic Consortium CHD Working Group. Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention. J Am Coll Cardiol. 2018 Oct 16;72(16):1883-1893. doi: 10.1016/j.jacc.2018.07.079. PMID: 30309464; PMCID: PMC6176870.
 

41: Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S, Ding J, Giulianini F, Holliday EG, Jackson AU, Li-Gao R, Lin WY, Luan J, Mangino M, Oldmeadow C, Prins BP, Qian Y, Sargurupremraj M, Shah N, Surendran P, Thériault S, Verweij N, Willems SM, Zhao JH, Amouyel P, Connell J, de Mutsert R, Doney ASF, Farrall M, Menni C, Morris AD, Noordam R, Paré G, Poulter NR, Shields DC, Stanton A, Thom S, Abecasis G, Amin N, Arking DE, Ayers KL, Barbieri CM, Batini C, Bis JC, Blake T, Bochud M, Boehnke M, Boerwinkle E, Boomsma DI, Bottinger EP, Braund PS, Brumat M, Campbell A, Campbell H, Chakravarti A, Chambers JC, Chauhan G, Ciullo M, Cocca M, Collins F, Cordell HJ, Davies G, de Borst MH, de Geus EJ, Deary IJ, Deelen J, Del Greco M F, Demirkale CY, Dörr M, Ehret GB, Elosua R, Enroth S, Erzurumluoglu AM, Ferreira T, Frånberg M, Franco OH, Gandin I, Gasparini P, Giedraitis V, Gieger C, Girotto G, Goel A, Gow AJ, Gudnason V, Guo X, Gyllensten U, Hamsten A, Harris TB, Harris SE, Hartman CA, Havulinna AS, Hicks AA, Hofer E, Hofman A, Hottenga JJ, Huffman JE, Hwang SJ, Ingelsson E, James A, Jansen R, Jarvelin MR, Joehanes R, Johansson Å, Johnson AD, Joshi PK, Jousilahti P, Jukema JW, Jula A, Kähönen M, Kathiresan S, Keavney BD, Khaw KT, Knekt P, Knight J, Kolcic I, Kooner JS, Koskinen S, Kristiansson K, Kutalik Z, Laan M, Larson M, Launer LJ, Lehne B, Lehtimäki T, Liewald DCM, Lin L, Lind L, Lindgren CM, Liu Y, Loos RJF, Lopez LM, Lu Y, Lyytikäinen LP, Mahajan A, Mamasoula C, Marrugat J, Marten J, Milaneschi Y, Morgan A, Morris AP, Morrison AC, Munson PJ, Nalls MA, Nandakumar P, Nelson CP, Niiranen T, Nolte IM, Nutile T, Oldehinkel AJ, Oostra BA, O'Reilly PF, Org E, Padmanabhan S, Palmas W, Palotie A, Pattie A, Penninx BWJH, Perola M, Peters A, Polasek O, Pramstaller PP, Nguyen QT, Raitakari OT, Ren M, Rettig R, Rice K, Ridker PM, Ried JS, Riese H, Ripatti S, Robino A, Rose LM, Rotter JI, Rudan I, Ruggiero D, Saba Y, Sala CF, Salomaa V, Samani NJ, Sarin AP, Schmidt R, Schmidt H, Shrine N, Siscovick D, Smith AV, Snieder H, Sõber S, Sorice R, Starr JM, Stott DJ, Strachan DP, Strawbridge RJ, Sundström J, Swertz MA, Taylor KD, Teumer A, Tobin MD, Tomaszewski M, Toniolo D, Traglia M, Trompet S, Tuomilehto J, Tzourio C, Uitterlinden AG, Vaez A, van der Most PJ, van Duijn CM, Vergnaud AC, Verwoert GC, Vitart V, Völker U, Vollenweider P, Vuckovic D, Watkins H, Wild SH, Willemsen G, Wilson JF, Wright AF, Yao J, Zemunik T, Zhang W, Attia JR, Butterworth AS, Chasman DI, Conen D, Cucca F, Danesh J, Hayward C, Howson JMM, Laakso M, Lakatta EG, Langenberg C, Melander O, Mook-Kanamori DO, Palmer CNA, Risch L, Scott RA, Scott RJ, Sever P, Spector TD, van der Harst P, Wareham NJ, Zeggini E, Levy D, Munroe PB, Newton-Cheh C, Brown MJ, Metspalu A, Hung AM, O'Donnell CJ, Edwards TL, Psaty BM, Tzoulaki I, Barnes MR, Wain LV, Elliott P, Caulfield MJ; Million Veteran Program. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet. 2018 Oct;50(10):1412-1425. doi: 10.1038/s41588-018-0205-x. Epub 2018 Sep 17. Erratum in: Nat Genet. 2018 Dec;50(12):1755. PMID: 30224653; PMCID: PMC6284793.
 

42: Owen B, Bojdo N, Jivkov A, Keavney B, Revell A. Structural modelling of the cardiovascular system. Biomech Model Mechanobiol. 2018 Oct;17(5):1217-1242. doi: 10.1007/s10237-018-1024-9. Epub 2018 Jun 18. PMID: 29911296; PMCID: PMC6154127.
 

43: Choy MK, Javierre BM, Williams SG, Baross SL, Liu Y, Wingett SW, Akbarov A, Wallace C, Freire-Pritchett P, Rugg-Gunn PJ, Spivakov M, Fraser P, Keavney BD. Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks. Nat Commun. 2018 Jun 28;9(1):2526. doi: 10.1038/s41467-018-04931-0. Erratum in: Nat Commun. 2018 Nov 12;9(1):4792. PMID: 29955040; PMCID: PMC6023870.
 

44: Bonner SJ, Asghar O, Roberts A, Vause S, Clarke B, Keavney B. Cardiovascular, obstetric and neonatal outcomes in women with previous fontan repair. Eur J Obstet Gynecol Reprod Biol. 2017 Dec;219:53-56. doi: 10.1016/j.ejogrb.2017.10.013. Epub 2017 Oct 16. Erratum in: Eur J Obstet Gynecol Reprod Biol. 2018 Jan 4;: PMID: 29054041.
 

45: Gupta P, Patel P, Štrauch B, Lai FY, Akbarov A, Gulsin GS, Beech A, Marešová V, Topham PS, Stanley A, Thurston H, Smith PR, Horne R, Widimský J, Keavney B, Heagerty A, Samani NJ, Williams B, Tomaszewski M. Biochemical Screening for Nonadherence Is Associated With Blood Pressure Reduction and Improvement in Adherence. Hypertension. 2017 Nov;70(5):1042-1048. doi: 10.1161/HYPERTENSIONAHA.117.09631. Epub 2017 Aug 28. PMID: 28847892; PMCID: PMC5642335.
 

46: Ridge LA, Mitchell K, Al-Anbaki A, Shaikh Qureshi WM, Stephen LA, Tenin G, Lu Y, Lupu IE, Clowes C, Robertson A, Barnes E, Wright JA, Keavney B, Ehler E, Lovell SC, Kadler KE, Hentges KE. Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development. PLoS Genet. 2017 Oct 30;13(10):e1007068. doi: 10.1371/journal.pgen.1007068. PMID: 29084269; PMCID: PMC5697871.
 

47: Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, Zeng L, Ntalla I, Lai FY, Hopewell JC, Giannakopoulou O, Jiang T, Hamby SE, Di Angelantonio E, Assimes TL, Bottinger EP, Chambers JC, Clarke R, Palmer CNA, Cubbon RM, Ellinor P, Ermel R, Evangelou E, Franks PW, Grace C, Gu D, Hingorani AD, Howson JMM, Ingelsson E, Kastrati A, Kessler T, Kyriakou T, Lehtimäki T, Lu X, Lu Y, März W, McPherson R, Metspalu A, Pujades-Rodriguez M, Ruusalepp A, Schadt EE, Schmidt AF, Sweeting MJ, Zalloua PA, AlGhalayini K, Keavney BD, Kooner JS, Loos RJF, Patel RS, Rutter MK, Tomaszewski M, Tzoulaki I, Zeggini E, Erdmann J, Dedoussis G, Björkegren JLM; EPIC-CVD Consortium; CARDIoGRAMplusC4D; UK Biobank CardioMetabolic Consortium CHD working group, Schunkert H, Farrall M, Danesh J, Samani NJ, Watkins H, Deloukas P. Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nat Genet. 2017 Sep;49(9):1385-1391. doi: 10.1038/ng.3913. Epub 2017 Jul 17. PMID: 28714975.
 

48: Yang C, Xu Y, Yu M, Lee D, Alharti S, Hellen N, Ahmad Shaik N, Banaganapalli B, Sheikh Ali Mohamoud H, Elango R, Przyborski S, Tenin G, Williams S, O'Sullivan J, Al-Radi OO, Atta J, Harding SE, Keavney B, Lako M, Armstrong L. Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis. Hum Mol Genet. 2017 Aug 15;26(16):3031-3045. doi: 10.1093/hmg/ddx140. PMID: 28521042; PMCID: PMC5886295.
 

49: Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP, Warren HR, Rose LM, Verwoert GC, Hottenga JJ, Strawbridge RJ, Esko T, Arking DE, Hwang SJ, Guo X, Kutalik Z, Trompet S, Shrine N, Teumer A, Ried JS, Bis JC, Smith AV, Amin N, Nolte IM, Lyytikäinen LP, Mahajan A, Wareham NJ, Hofer E, Joshi PK, Kristiansson K, Traglia M, Havulinna AS, Goel A, Nalls MA, Sõber S, Vuckovic D, Luan J, Del Greco M F, Ayers KL, Marrugat J, Ruggiero D, Lopez LM, Niiranen T, Enroth S, Jackson AU, Nelson CP, Huffman JE, Zhang W, Marten J, Gandin I, Harris SE, Zemunik T, Lu Y, Evangelou E, Shah N, de Borst MH, Mangino M, Prins BP, Campbell A, Li-Gao R, Chauhan G, Oldmeadow C, Abecasis G, Abedi M, Barbieri CM, Barnes MR, Batini C, Beilby J, Blake T, Boehnke M, Bottinger EP, Braund PS, Brown M, Brumat M, Campbell H, Chambers JC, Cocca M, Collins F, Connell J, Cordell HJ, Damman JJ, Davies G, de Geus EJ, de Mutsert R, Deelen J, Demirkale Y, Doney ASF, Dörr M, Farrall M, Ferreira T, Frånberg M, Gao H, Giedraitis V, Gieger C, Giulianini F, Gow AJ, Hamsten A, Harris TB, Hofman A, Holliday EG, Hui J, Jarvelin MR, Johansson Å, Johnson AD, Jousilahti P, Jula A, Kähönen M, Kathiresan S, Khaw KT, Kolcic I, Koskinen S, Langenberg C, Larson M, Launer LJ, Lehne B, Liewald DCM, Lin L, Lind L, Mach F, Mamasoula C, Menni C, Mifsud B, Milaneschi Y, Morgan A, Morris AD, Morrison AC, Munson PJ, Nandakumar P, Nguyen QT, Nutile T, Oldehinkel AJ, Oostra BA, Org E, Padmanabhan S, Palotie A, Paré G, Pattie A, Penninx BWJH, Poulter N, Pramstaller PP, Raitakari OT, Ren M, Rice K, Ridker PM, Riese H, Ripatti S, Robino A, Rotter JI, Rudan I, Saba Y, Saint Pierre A, Sala CF, Sarin AP, Schmidt R, Scott R, Seelen MA, Shields DC, Siscovick D, Sorice R, Stanton A, Stott DJ, Sundström J, Swertz M, Taylor KD, Thom S, Tzoulaki I, Tzourio C, Uitterlinden AG, Völker U, Vollenweider P, Wild S, Willemsen G, Wright AF, Yao J, Thériault S, Conen D, Attia J, Sever P, Debette S, Mook-Kanamori DO, Zeggini E, Spector TD, van der Harst P, Palmer CNA, Vergnaud AC, Loos RJF, Polasek O, Starr JM, Girotto G, Hayward C, Kooner JS, Lindgren CM, Vitart V, Samani NJ, Tuomilehto J, Gyllensten U, Knekt P, Deary IJ, Ciullo M, Elosua R, Keavney BD, Hicks AA, Scott RA, Gasparini P, Laan M, Liu Y, Watkins H, Hartman CA, Salomaa V, Toniolo D, Perola M, Wilson JF, Schmidt H, Zhao JH, Lehtimäki T, van Duijn CM, Gudnason V, Psaty BM, Peters A, Rettig R, James A, Jukema JW, Strachan DP, Palmas W, Metspalu A, Ingelsson E, Boomsma DI, Franco OH, Bochud M, Newton-Cheh C, Munroe PB, Elliott P, Chasman DI, Chakravarti A, Knight J, Morris AP, Levy D, Tobin MD, Snieder H, Caulfield MJ, Ehret GB. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017 Jul 24:HYPERTENSIONAHA.117.09438. doi: 10.1161/HYPERTENSIONAHA.117.09438. Epub ahead of print. PMID: 28739976; PMCID: PMC5783787.
 

50: Yang B, Zhou W, Jiao J, Nielsen JB, Mathis MR, Heydarpour M, Lettre G, Folkersen L, Prakash S, Schurmann C, Fritsche L, Farnum GA, Lin M, Othman M, Hornsby W, Driscoll A, Levasseur A, Thomas M, Farhat L, Dubé MP, Isselbacher EM, Franco-Cereceda A, Guo DC, Bottinger EP, Deeb GM, Booher A, Kheterpal S, Chen YE, Kang HM, Kitzman J, Cordell HJ, Keavney BD, Goodship JA, Ganesh SK, Abecasis G, Eagle KA, Boyle AP, Loos RJF, Eriksson P, Tardif JC, Brummett CM, Milewicz DM, Body SC, Willer CJ. Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve. Nat Commun. 2017 May 25;8:15481. doi: 10.1038/ncomms15481. PMID: 28541271; PMCID: PMC5458508.
 

51: Parikh JD, Kakarla J, Keavney B, O'Sullivan JJ, Ford GA, Blamire AM, Hollingsworth KG, Coats L. 4D flow MRI assessment of right atrial flow patterns in the normal heart - influence of caval vein arrangement and implications for the patent foramen ovale. PLoS One. 2017 Mar 10;12(3):e0173046. doi: 10.1371/journal.pone.0173046. PMID: 28282389; PMCID: PMC5345792.
 

52: Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, Karaman I, Lepe MP, O'Reilly PF, Knight J, Snieder H, Kato N, He J, Tai ES, Said MA, Porteous D, Alver M, Poulter N, Farrall M, Gansevoort RT, Padmanabhan S, Mägi R, Stanton A, Connell J, Bakker SJ, Metspalu A, Shields DC, Thom S, Brown M, Sever P, Esko T, Hayward C, van der Harst P, Saleheen D, Chowdhury R, Chambers JC, Chasman DI, Chakravarti A, Newton-Cheh C, Lindgren CM, Levy D, Kooner JS, Keavney B, Tomaszewski M, Samani NJ, Howson JM, Tobin MD, Munroe PB, Ehret GB, Wain LV; International Consortium of Blood Pressure (ICBP) 1000G Analyses; BIOS Consortium; Lifelines Cohort Study; Understanding Society Scientific group; CHD Exome+ Consortium; ExomeBP Consortium; T2D-GENES Consortium; GoT2DGenes Consortium; Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium; International Genomics of Blood Pressure (iGEN-BP) Consortium; UK Biobank CardioMetabolic Consortium BP working group. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet. 2017 Mar;49(3):403-415. doi: 10.1038/ng.3768. Epub 2017 Jan 30. Erratum in: Nat Genet. 2017 Sep 27;49(10 ):1558. PMID: 28135244; PMCID: PMC5972004.
 

53: Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF, Chasman DI, Nolte IM, Tragante V, van der Laan SW, Perry JR, Kong A; BIOS Consortium, Ahluwalia TS, Albrecht E, Yerges-Armstrong L, Atzmon G, Auro K, Ayers K, Bakshi A, Ben-Avraham D, Berger K, Bergman A, Bertram L, Bielak LF, Bjornsdottir G, Bonder MJ, Broer L, Bui M, Barbieri C, Cavadino A, Chavarro JE, Turman C, Concas MP, Cordell HJ, Davies G, Eibich P, Eriksson N, Esko T, Eriksson J, Falahi F, Felix JF, Fontana MA, Franke L, Gandin I, Gaskins AJ, Gieger C, Gunderson EP, Guo X, Hayward C, He C, Hofer E, Huang H, Joshi PK, Kanoni S, Karlsson R, Kiechl S, Kifley A, Kluttig A, Kraft P, Lagou V, Lecoeur C, Lahti J, Li-Gao R, Lind PA, Liu T, Makalic E, Mamasoula C, Matteson L, Mbarek H, McArdle PF, McMahon G, Meddens SF, Mihailov E, Miller M, Missmer SA, Monnereau C, van der Most PJ, Myhre R, Nalls MA, Nutile T, Kalafati IP, Porcu E, Prokopenko I, Rajan KB, Rich-Edwards J, Rietveld CA, Robino A, Rose LM, Rueedi R, Ryan KA, Saba Y, Schmidt D, Smith JA, Stolk L, Streeten E, Tönjes A, Thorleifsson G, Ulivi S, Wedenoja J, Wellmann J, Willeit P, Yao J, Yengo L, Zhao JH, Zhao W, Zhernakova DV, Amin N, Andrews H, Balkau B, Barzilai N, Bergmann S, Biino G, Bisgaard H, Bønnelykke K, Boomsma DI, Buring JE, Campbell H, Cappellani S, Ciullo M, Cox SR, Cucca F, Toniolo D, Davey-Smith G, Deary IJ, Dedoussis G, Deloukas P, van Duijn CM, de Geus EJ, Eriksson JG, Evans DA, Faul JD, Sala CF, Froguel P, Gasparini P, Girotto G, Grabe HJ, Greiser KH, Groenen PJ, de Haan HG, Haerting J, Harris TB, Heath AC, Heikkilä K, Hofman A, Homuth G, Holliday EG, Hopper J, Hyppönen E, Jacobsson B, Jaddoe VW, Johannesson M, Jugessur A, Kähönen M, Kajantie E, Kardia SL, Keavney B, Kolcic I, Koponen P, Kovacs P, Kronenberg F, Kutalik Z, La Bianca M, Lachance G, Iacono WG, Lai S, Lehtimäki T, Liewald DC; LifeLines Cohort Study, Lindgren CM, Liu Y, Luben R, Lucht M, Luoto R, Magnus P, Magnusson PK, Martin NG, McGue M, McQuillan R, Medland SE, Meisinger C, Mellström D, Metspalu A, Traglia M, Milani L, Mitchell P, Montgomery GW, Mook-Kanamori D, de Mutsert R, Nohr EA, Ohlsson C, Olsen J, Ong KK, Paternoster L, Pattie A, Penninx BW, Perola M, Peyser PA, Pirastu M, Polasek O, Power C, Kaprio J, Raffel LJ, Räikkönen K, Raitakari O, Ridker PM, Ring SM, Roll K, Rudan I, Ruggiero D, Rujescu D, Salomaa V, Schlessinger D, Schmidt H, Schmidt R, Schupf N, Smit J, Sorice R, Spector TD, Starr JM, Stöckl D, Strauch K, Stumvoll M, Swertz MA, Thorsteinsdottir U, Thurik AR, Timpson NJ, Tung JY, Uitterlinden AG, Vaccargiu S, Viikari J, Vitart V, Völzke H, Vollenweider P, Vuckovic D, Waage J, Wagner GG, Wang JJ, Wareham NJ, Weir DR, Willemsen G, Willeit J, Wright AF, Zondervan KT, Stefansson K, Krueger RF, Lee JJ, Benjamin DJ, Cesarini D, Koellinger PD, den Hoed M, Snieder H, Mills MC. Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet. 2016 Dec;48(12):1462-1472. doi: 10.1038/ng.3698. Epub 2016 Oct 31. PMID: 27798627; PMCID: PMC5695684.
 

54: Sifrim A, Hitz MP, Wilsdon A, Breckpot J, Turki SH, Thienpont B, McRae J, Fitzgerald TW, Singh T, Swaminathan GJ, Prigmore E, Rajan D, Abdul-Khaliq H, Banka S, Bauer UM, Bentham J, Berger F, Bhattacharya S, Bu'Lock F, Canham N, Colgiu IG, Cosgrove C, Cox H, Daehnert I, Daly A, Danesh J, Fryer A, Gewillig M, Hobson E, Hoff K, Homfray T; INTERVAL Study, Kahlert AK, Ketley A, Kramer HH, Lachlan K, Lampe AK, Louw JJ, Manickara AK, Manase D, McCarthy KP, Metcalfe K, Moore C, Newbury-Ecob R, Omer SO, Ouwehand WH, Park SM, Parker MJ, Pickardt T, Pollard MO, Robert L, Roberts DJ, Sambrook J, Setchfield K, Stiller B, Thornborough C, Toka O, Watkins H, Williams D, Wright M, Mital S, Daubeney PE, Keavney B, Goodship J; UK10K Consortium, Abu-Sulaiman RM, Klaassen S, Wright CF, Firth HV, Barrett JC, Devriendt K, FitzPatrick DR, Brook JD; Deciphering Developmental Disorders Study, Hurles ME. Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing. Nat Genet. 2016 Sep;48(9):1060-5. doi: 10.1038/ng.3627. Epub 2016 Aug 1. PMID: 27479907; PMCID: PMC5988037.
 

55: Ryan SL, Matheson E, Grossmann V, Sinclair P, Bashton M, Schwab C, Towers W, Partington M, Elliott A, Minto L, Richardson S, Rahman T, Keavney B, Skinner R, Bown N, Haferlach T, Vandenberghe P, Haferlach C, Santibanez-Koref M, Moorman AV, Kohlmann A, Irving JA, Harrison CJ. The role of the RAS pathway in iAMP21-ALL. Leukemia. 2016 Sep;30(9):1824-31. doi: 10.1038/leu.2016.80. Epub 2016 Apr 22. PMID: 27168466; PMCID: PMC5017527.
 

56: Wright EB, Henriques S, Houghton C, Clarke B, Keavney B, Venetucci L. Definition and delivery of an aortopathy bundle of care (ABC): a tool for improving diagnosis and management of Marfan syndrome and related conditions. Clin Med (Lond). 2016 Jun 1;16 Suppl 3(Suppl 3):s30. doi: 10.7861/clinmedicine.16-3-s30. PMID: 27252334; PMCID: PMC4989949.
 

57: Hanchard NA, Swaminathan S, Bucasas K, Furthner D, Fernbach S, Azamian MS, Wang X, Lewin M, Towbin JA, D'Alessandro LC, Morris SA, Dreyer W, Denfield S, Ayres NA, Franklin WJ, Justino H, Lantin-Hermoso MR, Ocampo EC, Santos AB, Parekh D, Moodie D, Jeewa A, Lawrence E, Allen HD, Penny DJ, Fraser CD, Lupski JR, Popoola M, Wadhwa L, Brook JD, Bu'Lock FA, Bhattacharya S, Lalani SR, Zender GA, Fitzgerald-Butt SM, Bowman J, Corsmeier D, White P, Lecerf K, Zapata G, Hernandez P, Goodship JA, Garg V, Keavney BD, Leal SM, Cordell HJ, Belmont JW, McBride KL. A genome-wide association study of congenital cardiovascular left- sided lesions shows association with a locus on chromosome 20. Hum Mol Genet. 2016 Jun 1;25(11):2331-2341. doi: 10.1093/hmg/ddw071. Epub 2016 Mar 9. PMID: 26965164; PMCID: PMC5081047.
 

58: Farooq V, Serruys PW, Mustafa AH, Mamas MA, Malik N, Alhous HA, El-Omar M, Hendry C, Rana DN, Shelton D, Wright PK, Narine N, Clarke B, Keavney B, Fath- Ordoubadi F, Fraser DG. Forward and back aspiration during ST-elevation myocardial infarction: a feasibility study. EuroIntervention. 2016 Apr 8;11(14):e1639-48. doi: 10.4244/EIJV11I14A315. PMID: 27056124.
 

59: Grozeva D, Carss K, Spasic-Boskovic O, Tejada MI, Gecz J, Shaw M, Corbett M, Haan E, Thompson E, Friend K, Hussain Z, Hackett A, Field M, Renieri A, Stevenson R, Schwartz C, Floyd JA, Bentham J, Cosgrove C, Keavney B, Bhattacharya S; Italian X-linked Mental Retardation Project; UK10K Consortium; GOLD Consortium, Hurles M, Raymond FL. Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability. Hum Mutat. 2015 Dec;36(12):1197-204. doi: 10.1002/humu.22901. Epub 2015 Sep 30. PMID: 26350204; PMCID: PMC4833192.
 

60: Anderson SG, Ratib K, Myint PK, Keavney B, Kwok CS, Zaman A, Ludman PF, de Belder MA, Nolan J, Mamas MA; British Cardiovascular Intervention Society; National Institute for Cardiovascular Outcomes Research. Impact of age on access site-related outcomes in 469,983 percutaneous coronary intervention procedures: Insights from the British Cardiovascular Intervention Society. Catheter Cardiovasc Interv. 2015 Nov 15;86(6):965-72. doi: 10.1002/ccd.25896. Epub 2015 Feb 25. PMID: 25676689.
 

61: Howey R, Mamasoula C, Töpf A, Nudel R, Goodship JA, Keavney BD, Cordell HJ. Increased Power for Detection of Parent-of-Origin Effects via the Use of Haplotype Estimation. Am J Hum Genet. 2015 Sep 3;97(3):419-34. doi: 10.1016/j.ajhg.2015.07.016. Epub 2015 Aug 27. PMID: 26320892; PMCID: PMC4564992.
 

62: Yang C, Al-Aama J, Stojkovic M, Keavney B, Trafford A, Lako M, Armstrong L. Concise Review: Cardiac Disease Modeling Using Induced Pluripotent Stem Cells. Stem Cells. 2015 Sep;33(9):2643-51. doi: 10.1002/stem.2070. Epub 2015 Jun 23. PMID: 26033645.
 

63: Lin Y, Guo X, Zhao B, Liu J, Da M, Wen Y, Hu Y, Ni B, Zhang K, Yang S, Xu J, Dai J, Wang X, Xia Y, Ma H, Jin G, Yu S, Liu J, Keavney BD, Goodship JA, Cordell HJ, Wang X, Shen H, Sha J, Zhou Z, Chen Y, Mo X, Luo L, Hu Z. Association analysis identifies new risk loci for congenital heart disease in Chinese populations. Nat Commun. 2015 Aug 18;6:8082. doi: 10.1038/ncomms9082. PMID: 26283027.
 

64: Boag SE, Das R, Shmeleva EV, Bagnall A, Egred M, Howard N, Bennaceur K, Zaman A, Keavney B, Spyridopoulos I. T lymphocytes and fractalkine contribute to myocardial ischemia/reperfusion injury in patients. J Clin Invest. 2015 Aug 3;125(8):3063-76. doi: 10.1172/JCI80055. Epub 2015 Jul 13. PMID: 26168217; PMCID: PMC4563749.
 

65: Martin RI, Babaei MS, Choy MK, Owens WA, Chico TJ, Keenan D, Yonan N, Koref MS, Keavney BD. Genetic variants associated with risk of atrial fibrillation regulate expression of PITX2, CAV1, MYOZ1, C9orf3 and FANCC. J Mol Cell Cardiol. 2015 Aug;85:207-14. doi: 10.1016/j.yjmcc.2015.06.005. Epub 2015 Jun 11. PMID: 26073630.
 

66: Kwok CS, Kontopantelis E, Myint PK, Zaman A, Berry C, Keavney B, Nolan J, Ludman PF, de Belder MA, Buchan I, Mamas MA; British Cardiovascular Intervention Society; National Institute for Cardiovascular Outcomes Research. Stroke following percutaneous coronary intervention: type-specific incidence, outcomes and determinants seen by the British Cardiovascular Intervention Society 2007-12. Eur Heart J. 2015 Jul 1;36(25):1618-28. doi: 10.1093/eurheartj/ehv113. Epub 2015 Apr 20. PMID: 25896077.
 

67: Shaheen R, Al Hashem A, Alghamdi MH, Seidahmad MZ, Wakil SM, Dagriri K, Keavney B, Goodship J, Alyousif S, Al-Habshan FM, Alhussein K, Almoisheer A, Ibrahim N, Alkuraya FS. Positional mapping of PRKD1, NRP1 and PRDM1 as novel candidate disease genes in truncus arteriosus. J Med Genet. 2015 May;52(5):322-9. doi: 10.1136/jmedgenet-2015-102992. Epub 2015 Feb 23. PMID: 25713110.
 

68: Kwok CS, Anderson SG, McAllister KS, Sperrin M, O'Kane PD, Keavney B, Nolan J, Myint PK, Zaman A, Buchan I, Ludman PF, de Belder MA, Mamas MA; British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research. Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: insights from the British Cardiovascular Intervention Society. Catheter Cardiovasc Interv. 2015 May;85(6):944-51. doi: 10.1002/ccd.25732. Epub 2014 Nov 27. PMID: 25408308.
 

69: Thorsson T, Russell WW, El-Kashlan N, Soemedi R, Levine J, Geisler SB, Ackley T, Tomita-Mitchell A, Rosenfeld JA, Töpf A, Tayeh M, Goodship J, Innis JW, Keavney B, Russell MW. Chromosomal Imbalances in Patients with Congenital Cardiac Defects: A Meta-analysis Reveals Novel Potential Critical Regions Involved in Heart Development. Congenit Heart Dis. 2015 May-Jun;10(3):193-208. doi: 10.1111/chd.12179. Epub 2014 Apr 11. PMID: 24720490.
 

70: Hoffmann J, Shmeleva EV, Boag SE, Fiser K, Bagnall A, Murali S, Dimmick I, Pircher H, Martin-Ruiz C, Egred M, Keavney B, von Zglinicki T, Das R, Todryk S, Spyridopoulos I. Myocardial ischemia and reperfusion leads to transient CD8 immune deficiency and accelerated immunosenescence in CMV-seropositive patients. Circ Res. 2015 Jan 2;116(1):87-98. doi: 10.1161/CIRCRESAHA.116.304393. Epub 2014 Nov 10. PMID: 25385851; PMCID: PMC4280279.
 

71: Houniet DT, Rahman TJ, Al Turki S, Hurles ME, Xu Y, Goodship J, Keavney B, Santibanez Koref M. Using population data for assessing next-generation sequencing performance. Bioinformatics. 2015 Jan 1;31(1):56-61. doi: 10.1093/bioinformatics/btu606. Epub 2014 Sep 17. PMID: 25236458; PMCID: PMC4271148.
 

72: Martin RI, Owens WA, Cunnington MS, Mayosi BM, Koref MS, Keavney BD. Chromosome 16q22 variants in a region associated with cardiovascular phenotypes correlate with ZFHX3 expression in a transcript-specific manner. BMC Genet. 2014 Dec 24;15:136. doi: 10.1186/s12863-014-0136-1. PMID: 25539802; PMCID: PMC4301889.
 

73: Mamas MA, Anderson SG, O'Kane PD, Keavney B, Nolan J, Oldroyd KG, Perera D, Redwood S, Zaman A, Ludman PF, de Belder MA; British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research. Impact of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: insights from the British Cardiovascular Intervention Society. Eur Heart J. 2014 Nov 14;35(43):3004-12a. doi: 10.1093/eurheartj/ehu303. Epub 2014 Aug 28. PMID: 25168601.
 

74: Forrester MA, Robertson L, Bayoumi N, Keavney BD, Barker RN, Vickers MA. Human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17A. Clin Exp Immunol. 2014 Nov;178(2):373-83. doi: 10.1111/cei.12408. PMID: 24975574; PMCID: PMC4233386.
 

75: Bennaceur K, Atwill M, Al Zhrany N, Hoffmann J, Keavney B, Breault D, Richardson G, von Zglinicki T, Saretzki G, Spyridopoulos I. Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism. Atherosclerosis. 2014 Oct;236(2):312-20. doi: 10.1016/j.atherosclerosis.2014.07.020. Epub 2014 Aug 4. PMID: 25127175.
 

76: Martin RI, Pogoryelova O, Koref MS, Bourke JP, Teare MD, Keavney BD. Atrial fibrillation associated with ivabradine treatment: meta-analysis of randomised controlled trials. Heart. 2014 Oct;100(19):1506-10. doi: 10.1136/heartjnl-2014-305482. Epub 2014 Jun 20. PMID: 24951486; PMCID: PMC4174120.
 

77: Collerton J, Kingston A, Yousaf F, Davies K, Kenny A, Neely D, Martin-Ruiz C, MacGowan G, Robinson L, Kirkwood TB, Keavney B. Utility of NT-proBNP as a rule-out test for left ventricular dysfunction in very old people with limiting dyspnoea: the Newcastle 85+ Study. BMC Cardiovasc Disord. 2014 Sep 26;14:128. doi: 10.1186/1471-2261-14-128. PMID: 25257704; PMCID: PMC4189162.
 

78: Best A, James K, Dalgliesh C, Hong E, Kheirolahi-Kouhestani M, Curk T, Xu Y, Danilenko M, Hussain R, Keavney B, Wipat A, Klinck R, Cowell IG, Cheong Lee K, Austin CA, Venables JP, Chabot B, Santibanez Koref M, Tyson-Capper A, Elliott DJ. Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons. Nat Commun. 2014 Sep 11;5:4760. doi: 10.1038/ncomms5760. PMID: 25208576; PMCID: PMC4175592.
 

79: Kwok CS, Loke YK, Pradhan S, Keavney B, El-Omar M, Mamas MA. Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis. Open Heart. 2014 Aug 5;1(1):e000092. doi: 10.1136/openhrt-2014-000092. PMID: 25332808; PMCID: PMC4189337.
 

80: Töpf A, Griffin HR, Glen E, Soemedi R, Brown DL, Hall D, Rahman TJ, Eloranta JJ, Jüngst C, Stuart AG, O'Sullivan J, Keavney BD, Goodship JA. Functionally significant, rare transcription factor variants in tetralogy of Fallot. PLoS One. 2014 Aug 5;9(8):e95453. doi: 10.1371/journal.pone.0095453. PMID: 25093829; PMCID: PMC4122343.
 

81: H3Africa Consortium, Rotimi C, Abayomi A, Abimiku A, Adabayeri VM, Adebamowo C, Adebiyi E, Ademola AD, Adeyemo A, Adu D, Affolabi D, Agongo G, Ajayi S, Akarolo-Anthony S, Akinyemi R, Akpalu A, Alberts M, Alonso Betancourt O, Alzohairy AM, Ameni G, Amodu O, Anabwani G, Andersen K, Arogundade F, Arulogun O, Asogun D, Bakare R, Balde N, Baniecki ML, Beiswanger C, Benkahla A, Bethke L, Boehnke M, Boima V, Brandful J, Brooks AI, Brosius FC, Brown C, Bucheton B, Burke DT, Burnett BG, Carrington-Lawrence S, Carstens N, Chisi J, Christoffels A, Cooper R, Cordell H, Crowther N, Croxton T, de Vries J, Derr L, Donkor P, Doumbia S, Duncanson A, Ekem I, El Sayed A, Engel ME, Enyaru JC, Everett D, Fadlelmola FM, Fakunle E, Fischbeck KH, Fischer A, Folarin O, Gamieldien J, Garry RF, Gaseitsiwe S, Gbadegesin R, Ghansah A, Giovanni M, Goesbeck P, Gomez- Olive FX, Grant DS, Grewal R, Guyer M, Hanchard NA, Happi CT, Hazelhurst S, Hennig BJ, Hertz- C, Fowler, Hide W, Hilderbrandt F, Hugo-Hamman C, Ibrahim ME, James R, Jaufeerally-Fakim Y, Jenkins C, Jentsch U, Jiang PP, Joloba M, Jongeneel V, Joubert F, Kader M, Kahn K, Kaleebu P, Kapiga SH, Kassim SK, Kasvosve I, Kayondo J, Keavney B, Kekitiinwa A, Khan SH, Kimmel P, King MC, Kleta R, Koffi M, Kopp J, Kretzler M, Kumuthini J, Kyobe S, Kyobutungi C, Lackland DT, Lacourciere KA, Landouré G, Lawlor R, Lehner T, Lesosky M, Levitt N, Littler K, Lombard Z, Loring JF, Lyantagaye S, Macleod A, Madden EB, Mahomva CR, Makani J, Mamven M, Marape M, Mardon G, Marshall P, Martin DP, Masiga D, Mason R, Mate-Kole M, Matovu E, Mayige M, Mayosi BM, Mbanya JC, McCurdy SA, McCarthy MI, McIlleron H, Mc'Ligeyo SO, Merle C, Mocumbi AO, Mondo C, Moran JV, Motala A, Moxey-Mims M, Mpoloka WS, Msefula CL, Mthiyane T, Mulder N, Mulugeta Gh, Mumba D, Musuku J, Nagdee M, Nash O, Ndiaye D, Nguyen AQ, Nicol M, Nkomazana O, Norris S, Nsangi B, Nyarko A, Nyirenda M, Obe E, Obiakor R, Oduro A, Ofori- Acquah SF, Ogah O, Ogendo S, Ohene-Frempong K, Ojo A, Olanrewaju T, Oli J, Osafo C, Ouwe Missi Oukem-Boyer O, Ovbiagele B, Owen A, Owolabi MO, Owolabi L, Owusu- Dabo E, Pare G, Parekh R, Patterton HG, Penno MB, Peterson J, Pieper R, Plange- Rhule J, Pollak M, Puzak J, Ramesar RS, Ramsay M, Rasooly R, Reddy S, Sabeti PC, Sagoe K, Salako T, Samassékou O, Sandhu MS, Sankoh O, Sarfo FS, Sarr M, Shaboodien G, Sidibe I, Simo G, Simuunza M, Smeeth L, Sobngwi E, Soodyall H, Sorgho H, Sow Bah O, Srinivasan S, Stein DJ, Susser ES, Swanepoel C, Tangwa G, Tareila A, Tastan Bishop O, Tayo B, Tiffin N, Tinto H, Tobin E, Tollman SM, Traoré M, Treadwell MJ, Troyer J, Tsimako-Johnstone M, Tukei V, Ulasi I, Ulenga N, van Rooyen B, Wachinou AP, Waddy SP, Wade A, Wayengera M, Whitworth J, Wideroff L, Winkler CA, Winnicki S, Wonkam A, Yewondwos M, sen T, Yozwiak N, Zar H. Research capacity. Enabling the genomic revolution in Africa. Science. 2014 Jun 20;344(6190):1346-8. doi: 10.1126/science.1251546. PMID: 24948725; PMCID: PMC4138491.
 

82: Kwok CS, Pradhan A, Khan MA, Anderson SG, Keavney BD, Myint PK, Mamas MA, Loke YK. Bariatric surgery and its impact on cardiovascular disease and mortality: a systematic review and meta-analysis. Int J Cardiol. 2014 Apr 15;173(1):20-8. doi: 10.1016/j.ijcard.2014.02.026. Epub 2014 Feb 24. PMID: 24636546.
 

83: Jiang Y, Habibollah S, Tilgner K, Collin J, Barta T, Al-Aama JY, Tesarov L, Hussain R, Trafford AW, Kirkwood G, Sernagor E, Eleftheriou CG, Przyborski S, Stojković M, Lako M, Keavney B, Armstrong L. An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes. Stem Cells Transl Med. 2014 Apr;3(4):416-23. doi: 10.5966/sctm.2013-0105. Epub 2014 Mar 3. PMID: 24591732; PMCID: PMC3973710.
 

84: Kwok CS, Rao SV, Myint PK, Keavney B, Nolan J, Ludman PF, de Belder MA, Loke YK, Mamas MA. Major bleeding after percutaneous coronary intervention and risk of subsequent mortality: a systematic review and meta-analysis. Open Heart. 2014 Feb 13;1(1):e000021. doi: 10.1136/openhrt-2013-000021. PMID: 25332786; PMCID: PMC4195929.
 

85: Mercier S, Küry S, Shaboodien G, Houniet DT, Khumalo NP, Bou-Hanna C, Bodak N, Cormier-Daire V, David A, Faivre L, Figarella-Branger D, Gherardi RK, Glen E, Hamel A, Laboisse C, Le Caignec C, Lindenbaum P, Magot A, Munnich A, Mussini JM, Pillay K, Rahman T, Redon R, Salort-Campana E, Santibanez-Koref M, Thauvin C, Barbarot S, Keavney B, Bézieau S, Mayosi BM. Mutations in FAM111B cause hereditary fibrosing poikiloderma with tendon contracture, myopathy, and pulmonary fibrosis. Am J Hum Genet. 2013 Dec 5;93(6):1100-7. doi: 10.1016/j.ajhg.2013.10.013. Epub 2013 Nov 21. PMID: 24268661; PMCID: PMC3853004.
 

86: Terao C, Bayoumi N, McKenzie CA, Zelenika D, Muro S, Mishima M, Connell JM, Vickers MA, Lathrop GM, Farrall M, Matsuda F, Keavney BD; Nagahama Cohort Research Group. Quantitative variation in plasma angiotensin-I converting enzyme activity shows allelic heterogeneity in the ABO blood group locus. Ann Hum Genet. 2013 Nov;77(6):465-71. doi: 10.1111/ahg.12034. Epub 2013 Aug 13. PMID: 23937567.
 

87: Bates MG, Newman JH, Jakovljevic DG, Hollingsworth KG, Alston CL, Zalewski P, Klawe JJ, Blamire AM, MacGowan GA, Keavney BD, Bourke JP, Schaefer A, McFarland R, Newton JL, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Defining cardiac adaptations and safety of endurance training in patients with m.3243A>G-related mitochondrial disease. Int J Cardiol. 2013 Oct 9;168(4):3599-608. doi: 10.1016/j.ijcard.2013.05.062. Epub 2013 Jun 3. PMID: 23742928; PMCID: PMC3819621.
 

88: Anand SS, Meyre D, Pare G, Bailey SD, Xie C, Zhang X, Montpetit A, Desai D, Bosch J, Mohan V, Diaz R, McQueen MJ, Cordell HJ, Keavney B, Yusuf S, Gaudet D, Gerstein H, Engert JC; EpiDREAM Genetics Investigators. Genetic information and the prediction of incident type 2 diabetes in a high-risk multiethnic population: the EpiDREAM genetic study. Diabetes Care. 2013 Sep;36(9):2836-42. doi: 10.2337/dc12-2553. Epub 2013 Apr 19. PMID: 23603917; PMCID: PMC3747911.
 

89: Badar A, Scaife J, Yan AT, Robinson SD, Zaman AG, Purcell IF, Ahmed JM, Egred M, Edwards RJ, Spyridopoulos I, Keavney BD, Bagnall AJ. Provision of gastroprotective medication and bleeding risk following acute coronary syndrome. J Invasive Cardiol. 2013 Aug;25(8):397-401. PMID: 23913604.
 

90: Mamasoula C, Prentice RR, Pierscionek T, Pangilinan F, Mills JL, Druschel C, Pass K, Russell MW, Hall D, Töpf A, Brown DL, Zelenika D, Bentham J, Cosgrove C, Bhattacharya S, Riveron JG, Setchfield K, Brook JD, Bu'Lock FA, Thornborough C, Rahman TJ, Doza JP, Tan HL, O'Sullivan J, Stuart AG, Blue G, Winlaw D, Postma AV, Mulder BJ, Zwinderman AH, van Engelen K, Moorman AF, Rauch A, Gewillig M, Breckpot J, Devriendt K, Lathrop GM, Farrall M, Goodship JA, Cordell HJ, Brody LC, Keavney BD. Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7697 cases and 13,125 controls. Circ Cardiovasc Genet. 2013 Aug;6(4):347-53. doi: 10.1161/CIRCGENETICS.113.000191. Epub 2013 Jul 22. PMID: 23876493; PMCID: PMC3855044.
 

91: Vermeer AM, van Engelen K, Postma AV, Baars MJ, Christiaans I, De Haij S, Klaassen S, Mulder BJ, Keavney B. Ebstein anomaly associated with left ventricular noncompaction: an autosomal dominant condition that can be caused by mutations in MYH7. Am J Med Genet C Semin Med Genet. 2013 Aug;163C(3):178-84. doi: 10.1002/ajmg.c.31365. Epub 2013 Jun 21. PMID: 23794396.
 

92: Cordell HJ, Bentham J, Topf A, Zelenika D, Heath S, Mamasoula C, Cosgrove C, Blue G, Granados-Riveron J, Setchfield K, Thornborough C, Breckpot J, Soemedi R, Martin R, Rahman TJ, Hall D, van Engelen K, Moorman AF, Zwinderman AH, Barnett P, Koopmann TT, Adriaens ME, Varro A, George AL Jr, dos Remedios C, Bishopric NH, Bezzina CR, O'Sullivan J, Gewillig M, Bu'Lock FA, Winlaw D, Bhattacharya S, Devriendt K, Brook JD, Mulder BJ, Mital S, Postma AV, Lathrop GM, Farrall M, Goodship JA, Keavney BD. Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Nat Genet. 2013 Jul;45(7):822-4. doi: 10.1038/ng.2637. Epub 2013 May 26. PMID: 23708191; PMCID: PMC3793630.
 

93: Bates MG, Hollingsworth KG, Newman JH, Jakovljevic DG, Blamire AM, MacGowan GA, Keavney BD, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers. Eur Heart J Cardiovasc Imaging. 2013 Jul;14(7):650-8. doi: 10.1093/ehjci/jes226. Epub 2012 Nov 4. PMID: 23129433; PMCID: PMC3681541.
94: Palomino Doza J, Topf A, Bentham J, Bhattacharya S, Cosgrove C, Brook JD, Granados-Riveron J, Bu'Lock FA, O'Sullivan J, Stuart AG, Parsons J, Relton C, Goodship J, Henderson DJ, Keavney B. Low-frequency intermediate penetrance variants in the ROCK1 gene predispose to Tetralogy of Fallot. BMC Genet. 2013 Jun 19;14:57. doi: 10.1186/1471-2156-14-57. PMID: 23782575; PMCID: PMC3734041.
 

95: Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S, Serbanovic-Canic J, Crossman DC, Keavney BD, Haase A, McMahon K, Gering M, Roehl H, Evans PC, Chico TJ. Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development. Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1257-63. doi: 10.1161/ATVBAHA.112.300590. Epub 2013 Apr 4. PMID: 23559631.
 

96: Cordell HJ, Töpf A, Mamasoula C, Postma AV, Bentham J, Zelenika D, Heath S, Blue G, Cosgrove C, Granados Riveron J, Darlay R, Soemedi R, Wilson IJ, Ayers KL, Rahman TJ, Hall D, Mulder BJ, Zwinderman AH, van Engelen K, Brook JD, Setchfield K, Bu'Lock FA, Thornborough C, O'Sullivan J, Stuart AG, Parsons J, Bhattacharya S, Winlaw D, Mital S, Gewillig M, Breckpot J, Devriendt K, Moorman AF, Rauch A, Lathrop GM, Keavney BD, Goodship JA. Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. Hum Mol Genet. 2013 Apr 1;22(7):1473-81. doi: 10.1093/hmg/dds552. Epub 2013 Jan 7. PMID: 23297363; PMCID: PMC3596849.
 

97: van Engelen K, Postma AV, van de Meerakker JB, Roos-Hesselink JW, Helderman-van den Enden AT, Vliegen HW, Rahman T, Baars MJ, Sels JW, Bauer U, Pickardt T, Sperling SR, Moorman AF, Keavney B, Goodship J, Klaassen S, Mulder BJ. Ebstein's anomaly may be caused by mutations in the sarcomere protein gene MYH7. Neth Heart J. 2013 Mar;21(3):113-7. doi: 10.1007/s12471-011-0141-1. PMID: 21604106; PMCID: PMC3578524.
 

98: Harper AR, Mayosi BM, Rodriguez A, Rahman T, Hall D, Mamasoula C, Avery PJ, Keavney BD. Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass. PLoS One. 2013;8(1):e55061. doi: 10.1371/journal.pone.0055061. Epub 2013 Jan 25. PMID: 23372812; PMCID: PMC3555935.
 

99: Lee K, Santibanez-Koref M, Polvikoski T, Birchall D, Mendelow AD, Keavney B. Increased expression of fatty acid binding protein 4 and leptin in resident macrophages characterises atherosclerotic plaque rupture. Atherosclerosis. 2013 Jan;226(1):74-81. doi: 10.1016/j.atherosclerosis.2012.09.037. Epub 2012 Oct 5. PMID: 23122912; PMCID: PMC3566542.
 

100: Twigg SR, Lloyd D, Jenkins D, Elçioglu NE, Cooper CD, Al-Sannaa N, Annagür A, Gillessen-Kaesbach G, Hüning I, Knight SJ, Goodship JA, Keavney BD, Beales PL, Gileadi O, McGowan SJ, Wilkie AO. Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization. Am J Hum Genet. 2012 Nov 2;91(5):897-905. doi: 10.1016/j.ajhg.2012.08.027. Epub 2012 Oct 11. PMID: 23063620; PMCID: PMC3487118.

 

101: Yousaf F, Collerton J, Kingston A, Kenny A, Davies K, Jagger C, Robinson L, Kirkwood TB, Keavney B. Prevalence of left ventricular dysfunction in a UK community sample of very old people: the Newcastle 85+ study. Heart. 2012 Oct;98(19):1418-23. doi: 10.1136/heartjnl-2012-302457. Epub 2012 Aug 2. PMID: 22859497; PMCID: PMC3437786.
 

102: Soemedi R, Wilson IJ, Bentham J, Darlay R, Töpf A, Zelenika D, Cosgrove C, Setchfield K, Thornborough C, Granados-Riveron J, Blue GM, Breckpot J, Hellens S, Zwolinkski S, Glen E, Mamasoula C, Rahman TJ, Hall D, Rauch A, Devriendt K, Gewillig M, O' Sullivan J, Winlaw DS, Bu'Lock F, Brook JD, Bhattacharya S, Lathrop M, Santibanez-Koref M, Cordell HJ, Goodship JA, Keavney BD. Contribution of global rare copy-number variants to the risk of sporadic congenital heart disease. Am J Hum Genet. 2012 Sep 7;91(3):489-501. doi: 10.1016/j.ajhg.2012.08.003. Epub 2012 Aug 30. PMID: 22939634; PMCID: PMC3511986.
 

103: Helgadottir A, Gretarsdottir S, Thorleifsson G, Holm H, Patel RS, Gudnason T, Jones GT, van Rij AM, Eapen DJ, Baas AF, Tregouet DA, Morange PE, Emmerich J, Lindblad B, Gottsäter A, Kiemeny LA, Lindholt JS, Sakalihasan N, Ferrell RE, Carey DJ, Elmore JR, Tsao PS, Grarup N, Jørgensen T, Witte DR, Hansen T, Pedersen O, Pola R, Gaetani E, Magnadottir HB, Wijmenga C, Tromp G, Ronkainen A, Ruigrok YM, Blankensteijn JD, Mueller T, Wells PS, Corral J, Soria JM, Souto JC, Peden JF, Jalilzadeh S, Mayosi BM, Keavney B, Strawbridge RJ, Sabater-Lleal M, Gertow K, Baldassarre D, Nyyssönen K, Rauramaa R, Smit AJ, Mannarino E, Giral P, Tremoli E, de Faire U, Humphries SE, Hamsten A, Haraldsdottir V, Olafsson I, Magnusson MK, Samani NJ, Levey AI, Markus HS, Kostulas K, Dichgans M, Berger K, Kuhlenbäumer G, Ringelstein EB, Stoll M, Seedorf U, Rothwell PM, Powell JT, Kuivaniemi H, Onundarson PT, Valdimarsson E, Matthiasson SE, Gudbjartsson DF, Thorgeirsson G, Quyyumi AA, Watkins H, Farrall M, Thorsteinsdottir U, Stefansson K. Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. J Am Coll Cardiol. 2012 Aug 21;60(8):722-9. doi: 10.1016/j.jacc.2012.01.078. PMID: 22898070.
 

104: Goodship JA, Hall D, Topf A, Mamasoula C, Griffin H, Rahman TJ, Glen E, Tan H, Palomino Doza J, Relton CL, Bentham J, Bhattacharya S, Cosgrove C, Brook D, Granados-Riveron J, Bu'Lock FA, O'Sullivan J, Stuart AG, Parsons J, Cordell HJ, Keavney B. A common variant in the PTPN11 gene contributes to the risk of tetralogy of Fallot. Circ Cardiovasc Genet. 2012 Jun;5(3):287-92. doi: 10.1161/CIRCGENETICS.111.962035. Epub 2012 Apr 13. PMID: 22503907; PMCID: PMC4643453.
 

105: Horvath R, Holinski-Feder E, Neeve VC, Pyle A, Griffin H, Ashok D, Foley C, Hudson G, Rautenstrauss B, Nürnberg G, Nürnberg P, Kortler J, Neitzel B, Bässmann I, Rahman T, Keavney B, Loughlin J, Hambleton S, Schoser B, Lochmüller H, Santibanez-Koref M, Chinnery PF. A new phenotype of brain iron accumulation with dystonia, optic atrophy, and peripheral neuropathy. Mov Disord. 2012 May;27(6):789-93. doi: 10.1002/mds.24980. Epub 2012 Apr 16. PMID: 22508347.
 

106: Tan HL, Glen E, Töpf A, Hall D, O'Sullivan JJ, Sneddon L, Wren C, Avery P, Lewis RJ, ten Dijke P, Arthur HM, Goodship JA, Keavney BD. Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation. Hum Mutat. 2012 Apr;33(4):720-7. doi: 10.1002/humu.22030. Epub 2012 Feb 14. PMID: 22275001; PMCID: PMC3492913.
 

107: Soemedi R, Topf A, Wilson IJ, Darlay R, Rahman T, Glen E, Hall D, Huang N, Bentham J, Bhattacharya S, Cosgrove C, Brook JD, Granados-Riveron J, Setchfield K, Bu'lock F, Thornborough C, Devriendt K, Breckpot J, Hofbeck M, Lathrop M, Rauch A, Blue GM, Winlaw DS, Hurles M, Santibanez-Koref M, Cordell HJ, Goodship JA, Keavney BD. Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls. Hum Mol Genet. 2012 Apr 1;21(7):1513-20. doi: 10.1093/hmg/ddr589. Epub 2011 Dec 22. PMID: 22199024; PMCID: PMC3298277.
 

108: Hollingsworth KG, Blamire AM, Keavney BD, Macgowan GA. Left ventricular torsion, energetics, and diastolic function in normal human aging. Am J Physiol Heart Circ Physiol. 2012 Feb 15;302(4):H885-92. doi: 10.1152/ajpheart.00985.2011. Epub 2011 Dec 16. PMID: 22180656; PMCID: PMC3322734.
 

109: Chen CM, Bentham J, Cosgrove C, Braganca J, Cuenda A, Bamforth SD, Schneider JE, Watkins H, Keavney B, Davies B, Bhattacharya S. Functional significance of SRJ domain mutations in CITED2. PLoS One. 2012;7(10):e46256. doi: 10.1371/journal.pone.0046256. Epub 2012 Oct 17. PMID: 23082118; PMCID: PMC3474824.
 

110: Hoffmann J, Fiser K, Weaver J, Dimmick I, Loeher M, Pircher H, Martin-Ruiz C, Veerasamy M, Keavney B, von Zglinicki T, Spyridopoulos I. High-throughput 13-parameter immunophenotyping identifies shifts in the circulating T-cell compartment following reperfusion in patients with acute myocardial infarction. PLoS One. 2012;7(10):e47155. doi: 10.1371/journal.pone.0047155. Epub 2012 Oct 16. PMID: 23077561; PMCID: PMC3473067.
 

111: Avery PJ, Patel SK, Ibrahim IM, Walker M, Keavney BD. Common variation in the adiponectin gene has an effect on systolic blood pressure. J Hum Hypertens. 2011 Dec;25(12):719-24. doi: 10.1038/jhh.2010.122. Epub 2011 Jan 20. PMID: 21248784.
 

112: Martin-Ruiz C, Jagger C, Kingston A, Collerton J, Catt M, Davies K, Dunn M, Hilkens C, Keavney B, Pearce SH, den Elzen WP, Talbot D, Wiley L, Bond J, Mathers JC, Eccles MP, Robinson L, James O, Kirkwood TB, von Zglinicki T. Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study. Mech Ageing Dev. 2011 Oct;132(10):496-502. doi: 10.1016/j.mad.2011.08.001. Epub 2011 Aug 16. PMID: 21864562.
 

113: Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M. Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood. 2011 Sep 8;118(10):2656-8. doi: 10.1182/blood-2011-06-360313. Epub 2011 Jul 15. PMID: 21765025; PMCID: PMC5137783.
 

114: Cunnington MS, Keavney B. Genetic mechanisms mediating atherosclerosis susceptibility at the chromosome 9p21 locus. Curr Atheroscler Rep. 2011 Jun;13(3):193-201. doi: 10.1007/s11883-011-0178-z. PMID: 21487702.
 

115: Rahman TJ, Mayosi BM, Hall D, Avery PJ, Stewart PM, Connell JM, Watkins H, Keavney B. Common variation at the 11-β hydroxysteroid dehydrogenase type 1 gene is associated with left ventricular mass. Circ Cardiovasc Genet. 2011 Apr;4(2):156-62. doi: 10.1161/CIRCGENETICS.110.958496. Epub 2011 Mar 14. PMID: 21402901.
 

116: Hall D, Mayosi BM, Rahman TJ, Avery PJ, Watkins HC, Keavney B. Common variation in the CD36 (fatty acid translocase) gene is associated with left- ventricular mass. J Hypertens. 2011 Apr;29(4):690-5. doi: 10.1097/HJH.0b013e3283440115. PMID: 21346626; PMCID: PMC4454277.
 

117: Siddle KJ, Goodship JA, Keavney B, Santibanez-Koref MF. Bases adjacent to mononucleotide repeats show an increased single nucleotide polymorphism frequency in the human genome. Bioinformatics. 2011 Apr 1;27(7):895-8. doi: 10.1093/bioinformatics/btr067. Epub 2011 Feb 11. PMID: 21317137.
 

118: Keavney B. C reactive protein and the risk of cardiovascular disease. BMJ. 2011 Feb 15;342:d144. doi: 10.1136/bmj.d144. PMID: 21325003.
 

119: Postma AV, van Engelen K, van de Meerakker J, Rahman T, Probst S, Baars MJ, Bauer U, Pickardt T, Sperling SR, Berger F, Moorman AF, Mulder BJ, Thierfelder L, Keavney B, Goodship J, Klaassen S. Mutations in the sarcomere gene MYH7 in Ebstein anomaly. Circ Cardiovasc Genet. 2011 Feb;4(1):43-50. doi: 10.1161/CIRCGENETICS.110.957985. Epub 2010 Dec 2. PMID: 21127202.
 

120: Rahman TJ, Walker EA, Mayosi BM, Hall DH, Avery PJ, Connell JM, Watkins H, Stewart PM, Keavney B. Genotype at the P554L variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness. PLoS One. 2011;6(8):e23248. doi: 10.1371/journal.pone.0023248. Epub 2011 Aug 12. PMID: 21858044; PMCID: PMC3155541.
 

121: Kiechl S, Laxton RC, Xiao Q, Hernesniemi JA, Raitakari OT, Kähönen M, Mayosi BM, Jula A, Moilanen L, Willeit J, Watkins H, Samani NJ, Lehtimäki TJ, Keavney B, Xu Q, Ye S. Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2678-83. doi: 10.1161/ATVBAHA.110.213785. Epub 2010 Sep 16. PMID: 20847302.
 

122: Griffin HR, Töpf A, Glen E, Zweier C, Stuart AG, Parsons J, Peart I, Deanfield J, O'Sullivan J, Rauch A, Scambler P, Burn J, Cordell HJ, Keavney B, Goodship JA. Systematic survey of variants in TBX1 in non-syndromic tetralogy of Fallot identifies a novel 57 base pair deletion that reduces transcriptional activity but finds no evidence for association with common variants. Heart. 2010 Oct;96(20):1651-5. doi: 10.1136/hrt.2010.200121. PMID: 20937753; PMCID: PMC2976076.
 

123: Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S; DREAM investigators. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Diabetes Care. 2010 Oct;33(10):2250-3. doi: 10.2337/dc10-0452. Epub 2010 Jul 13. PMID: 20628086; PMCID: PMC2945168.
 

124: Lang CC, Gupta S, Kalra P, Keavney B, Menown I, Morley C, Padmanabhan S. Elevated heart rate and cardiovascular outcomes in patients with coronary artery disease: clinical evidence and pathophysiological mechanisms. Atherosclerosis. 2010 Sep;212(1):1-8. doi: 10.1016/j.atherosclerosis.2010.01.029. Epub 2010 Jan 29. PMID: 20152981.
 

125: Keavney B. Left, right: a step forward in understanding transposition of the great arteries. Heart. 2010 May;96(9):653-5. doi: 10.1136/hrt.2009.188938. PMID: 20424146.
 

126: Cunnington MS, Santibanez Koref M, Mayosi BM, Burn J, Keavney B. Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression. PLoS Genet. 2010 Apr 8;6(4):e1000899. doi: 10.1371/journal.pgen.1000899. PMID: 20386740; PMCID: PMC2851566.
 

127: van Engelen K, Topf A, Keavney BD, Goodship JA, van der Velde ET, Baars MJ, Snijder S, Moorman AF, Postma AV, Mulder BJ. 22q11.2 Deletion Syndrome is under- recognised in adult patients with tetralogy of Fallot and pulmonary atresia. Heart. 2010 Apr;96(8):621-4. doi: 10.1136/hrt.2009.182642. PMID: 20357389.
 

128: Keavney B. The interleukin-1 cluster, dyslipidaemia and risk of myocardial infarction. BMC Med. 2010 Jan 13;8:6. doi: 10.1186/1741-7015-8-6. PMID: 20070881; PMCID: PMC2822811.
 

129: Cunnington MS, Kay C, Avery PJ, Mayosi BM, Koref MS, Keavney B. STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression. BMC Med Genet. 2009 Dec 14;10:135. doi: 10.1186/1471-2350-10-135. PMID: 20003416; PMCID: PMC2803166.
 

130: Alvarez-Madrazo S, Padmanabhan S, Mayosi BM, Watkins H, Avery P, Wallace AM, Fraser R, Davies E, Keavney B, Connell JM. Familial and phenotypic associations of the aldosterone Renin ratio. J Clin Endocrinol Metab. 2009 Nov;94(11):4324-33. doi: 10.1210/jc.2009-1406. Epub 2009 Oct 9. PMID: 19820005.
 

131: Thomas HE, Avery PJ, Ahmed JM, Edwards R, Purcell I, Zaman AG, Arthur HM, Keavney BD. Local vessel injury following percutaneous coronary intervention does not promote early mobilisation of endothelial progenitor cells in the absence of myocardial necrosis. Heart. 2009 Apr;95(7):555-8. doi: 10.1136/hrt.2008.146662. Epub 2008 Oct 31. PMID: 18977801.
 

132: Leong FT, Freeman LJ, Keavney BD. Fresh fields and pathways new: recent genetic insights into cardiac malformation. Heart. 2009 Mar;95(6):442-7. doi: 10.1136/hrt.2006.105130. PMID: 19252006.
 

133: Cunnington MS, Mayosi BM, Hall DH, Avery PJ, Farrall M, Vickers MA, Watkins H, Keavney B. Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes. Atherosclerosis. 2009 Mar;203(1):41-4. doi: 10.1016/j.atherosclerosis.2008.06.025. Epub 2008 Jul 3. PMID: 18675980; PMCID: PMC2654912.
 

134: Anand SS, Xie C, Paré G, Montpetit A, Rangarajan S, McQueen MJ, Cordell HJ, Keavney B, Yusuf S, Hudson TJ, Engert JC; INTERHEART Investigators. Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study. Circ Cardiovasc Genet. 2009 Feb;2(1):16-25. doi: 10.1161/CIRCGENETICS.108.813709. Epub 2009 Jan 23. PMID: 20031563.
 

135: Thomas HE, Parry G, Dark JH, Arthur HM, Keavney BD. Circulating endothelial progenitor cell numbers are not associated with donor organ age or allograft vasculopathy in cardiac transplant recipients. Atherosclerosis. 2009 Feb;202(2):612-6. doi: 10.1016/j.atherosclerosis.2008.05.020. Epub 2008 May 20. PMID: 18589426.
 

136: Griffin HR, Hall DH, Topf A, Eden J, Stuart AG, Parsons J, Peart I, Deanfield JE, O'Sullivan J, Babu-Narayan SV, Gatzoulis MA, Bu'lock FA, Bhattacharya S, Bentham J, Farrall M, Granados Riveron J, Brook JD, Burn J, Cordell HJ, Goodship JA, Keavney B. Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation. PLoS One. 2009;4(3):e4978. doi: 10.1371/journal.pone.0004978. Epub 2009 Mar 24. PMID: 19308252; PMCID: PMC2654913.
 

137: Palomino-Doza J, Rahman TJ, Avery PJ, Mayosi BM, Farrall M, Watkins H, Edwards CR, Keavney B. Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. Hypertension. 2008 Nov;52(5):980-5. doi: 10.1161/HYPERTENSIONAHA.108.113282. Epub 2008 Oct 13. PMID: 18852390.
 

138: Keavney B. More evidence against a causal association between C-reactive protein and diabetes. PLoS Med. 2008 Aug 12;5(8):e174. doi: 10.1371/journal.pmed.0050174. PMID: 18700815; PMCID: PMC2504485.
 

139: Thompson A, Di Angelantonio E, Sarwar N, Erqou S, Saleheen D, Dullaart RP, Keavney B, Ye Z, Danesh J. Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA. 2008 Jun 18;299(23):2777-88. doi: 10.1001/jama.299.23.2777. PMID: 18560005.
 

140: Rahman T, Baker M, Hall DH, Avery PJ, Keavney B. Common genetic variation in the type A endothelin-1 receptor is associated with ambulatory blood pressure: a family study. J Hum Hypertens. 2008 Apr;22(4):282-8. doi: 10.1038/sj.jhh.1002322. Epub 2008 Jan 3. PMID: 18172451.
 

141: Thomas HE, Redgrave R, Cunnington MS, Avery P, Keavney BD, Arthur HM. Circulating endothelial progenitor cells exhibit diurnal variation. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):e21-2. doi: 10.1161/ATVBAHA.107.160317. PMID: 18296584.
 

142: Gaukrodger N, Avery PJ, Keavney B. Plasma potassium level is associated with common genetic variation in the beta-subunit of the epithelial sodium channel. Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R1068-72. doi: 10.1152/ajpregu.00732.2007. Epub 2008 Jan 9. PMID: 18184758.
 

143: Mayosi BM, Avery PJ, Farrall M, Keavney B, Watkins H. Genome-wide linkage analysis of electrocardiographic and echocardiographic left ventricular hypertrophy in families with hypertension. Eur Heart J. 2008 Feb;29(4):525-30. doi: 10.1093/eurheartj/ehn028. PMID: 18276622.
 

144: Serre D, Montpetit A, Paré G, Engert JC, Yusuf S, Keavney B, Hudson TJ, Anand S. Correction of population stratification in large multi-ethnic association studies. PLoS One. 2008 Jan 2;3(1):e1382. doi: 10.1371/journal.pone.0001382. PMID: 18196181; PMCID: PMC2198793.
 

145: Baker M, Rahman T, Hall D, Avery PJ, Mayosi BM, Connell JM, Farrall M, Watkins H, Keavney B. The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: a possible explanation for heterogeneity in genetic association studies of AGT and hypertension. Int J Epidemiol. 2007 Dec;36(6):1356-62. doi: 10.1093/ije/dym213. Epub 2007 Nov 12. PMID: 17998241.
 

146: Bennet AM, Di Angelantonio E, Ye Z, Wensley F, Dahlin A, Ahlbom A, Keavney B, Collins R, Wiman B, de Faire U, Danesh J. Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA. 2007 Sep 19;298(11):1300-11. doi: 10.1001/jama.298.11.1300. PMID: 17878422.
 

147: Collerton J, Martin-Ruiz C, Kenny A, Barrass K, von Zglinicki T, Kirkwood T, Keavney B; Newcastle 85+ Core Study Team. Telomere length is associated with left ventricular function in the oldest old: the Newcastle 85+ study. Eur Heart J. 2007 Jan;28(2):172-6. doi: 10.1093/eurheartj/ehl437. Epub 2007 Jan 10. PMID: 17215319.
 

148: Imrie H, Freel M, Mayosi BM, Davies E, Fraser R, Ingram M, Cordell HJ, Farrall M, Avery PJ, Watkins H, Keavney B, Connell JM. Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene. J Clin Endocrinol Metab. 2006 Dec;91(12):5051-6. doi: 10.1210/jc.2006-1481. Epub 2006 Sep 19. PMID: 16984984.
 

149: Hall DH, Rahman T, Avery PJ, Keavney B. INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families. BMC Med Genet. 2006 Nov 30;7:83. doi: 10.1186/1471-2350-7-83. PMID: 17137505; PMCID: PMC1698479.
 

150: Keavney B. Toll the bell for another genetic association? Eur Heart J. 2006 Nov;27(21):2489-90. doi: 10.1093/eurheartj/ehl299. Epub 2006 Oct 6. PMID: 17028110.
 

151: Keavney B, Danesh J, Parish S, Palmer A, Clark S, Youngman L, Delépine M, Lathrop M, Peto R, Collins R. Fibrinogen and coronary heart disease: test of causality by 'Mendelian randomization'. Int J Epidemiol. 2006 Aug;35(4):935-43. doi: 10.1093/ije/dyl114. Epub 2006 Jul 26. PMID: 16870675.
 

152: Ye Z, Liu EH, Higgins JP, Keavney BD, Lowe GD, Collins R, Danesh J. Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls. Lancet. 2006 Feb 25;367(9511):651-8. doi: 10.1016/S0140-6736(06)68263-9. PMID: 16503463.
 

153: Mayosi BM, Avery PJ, Baker M, Gaukrodger N, Imrie H, Green FR, Farrall M, Watkins H, Keavney B. Genotype at the -174G/C polymorphism of the interleukin-6 gene is associated with common carotid artery intimal-medial thickness: family study and meta-analysis. Stroke. 2005 Oct;36(10):2215-9. doi: 10.1161/01.STR.0000182254.47941.96. Epub 2005 Sep 22. PMID: 16179573.
 

154: Baker M, Gaukrodger N, Mayosi BM, Imrie H, Farrall M, Watkins H, Connell JM, Avery PJ, Keavney B. Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study. Diabetes. 2005 Aug;54(8):2492-6. doi: 10.2337/diabetes.54.8.2492. PMID: 16046320.
 

155: Gaukrodger N, Mayosi BM, Imrie H, Avery P, Baker M, Connell JM, Watkins H, Farrall M, Keavney B. A rare variant of the leptin gene has large effects on blood pressure and carotid intima-medial thickness: a study of 1428 individuals in 248 families. J Med Genet. 2005 Jun;42(6):474-8. doi: 10.1136/jmg.2004.027631. PMID: 15937081; PMCID: PMC1736073.
 

156: Keavney B, Mayosi B, Gaukrodger N, Imrie H, Baker M, Fraser R, Ingram M, Watkins H, Farrall M, Davies E, Connell J. Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. J Clin Endocrinol Metab. 2005 Feb;90(2):1072-7. doi: 10.1210/jc.2004-0870. Epub 2004 Nov 2. PMID: 15522937.
 

157: Keavney B, Palmer A, Parish S, Clark S, Youngman L, Danesh J, McKenzie C, Delépine M, Lathrop M, Peto R, Collins R; International Studies of Infarct Survival (ISIS) Collaborators. Lipid-related genes and myocardial infarction in 4685 cases and 3460 controls: discrepancies between genotype, blood lipid concentrations, and coronary disease risk. Int J Epidemiol. 2004 Oct;33(5):1002-13. doi: 10.1093/ije/dyh275. Epub 2004 Jul 15. PMID: 15256516.
 

158: Wheeler JG, Keavney BD, Watkins H, Collins R, Danesh J. Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies. Lancet. 2004 Feb 28;363(9410):689-95. doi: 10.1016/S0140-6736(04)15642-0. PMID: 15001326.
 

159: Keavney B. Commentary: Katan's remarkable foresight: genes and causality 18 years on. Int J Epidemiol. 2004 Feb;33(1):11-4. doi: 10.1093/ije/dyh056. PMID: 15075138.
 

160: Mayosi BM, Keavney B, Watkins H, Farrall M. Measured haplotype analysis of the aldosterone synthase gene and heart size. Eur J Hum Genet. 2003 May;11(5):395-401. doi: 10.1038/sj.ejhg.5200967. Erratum in: Eur J Hum Genet. 2005 Aug;13(8):992. PMID: 12734545.
 

161: Keavney B. Outcome following percutaneous coronary intervention: not, so far, in our genes. Heart. 2003 Mar;89(3):247-8. doi: 10.1136/heart.89.3.247. PMID: 12591817; PMCID: PMC1767596.
 

162: Keavney B, Parish S, Palmer A, Clark S, Youngman L, Danesh J, McKenzie C, Delépine M, Lathrop M, Peto R, Collins R; International Studies of Infarct Survival (ISIS) Collaborators. Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E epsilon2/epsilon3/epsilon4 genotype. Lancet. 2003 Feb 1;361(9355):396-8. doi: 10.1016/S0140-6736(03)12386-0. PMID: 12573381.
 

163: Mayosi BM, Keavney B, Kardos A, Davies CH, Ratcliffe PJ, Farrall M, Watkins H. Electrocardiographic measures of left ventricular hypertrophy show greater heritability than echocardiographic left ventricular mass. Eur Heart J. 2002 Dec;23(24):1963-71. doi: 10.1053/euhj.2002.3288. PMID: 12473259.
 

164: Bonnici F, Keavney B, Collins R, Danesh J. Angiotensin converting enzyme insertion or deletion polymorphism and coronary restenosis: meta-analysis of 16 studies. BMJ. 2002 Sep 7;325(7363):517-20. doi: 10.1136/bmj.325.7363.517. PMID: 12217990; PMCID: PMC121331.
 

165: Keavney B. Common genetic polymorphisms and coronary heart disease. Semin Vasc Med. 2002 Aug;2(3):233-41. doi: 10.1055/s-2002-35391. PMID: 16222616.
 

166: Keavney B. Genetic epidemiological studies of coronary heart disease. Int J Epidemiol. 2002 Aug;31(4):730-6. doi: 10.1093/ije/31.4.730. PMID: 12177010.
 

167: Vickers MA, Green FR, Terry C, Mayosi BM, Julier C, Lathrop M, Ratcliffe PJ, Watkins HC, Keavney B. Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein. Cardiovasc Res. 2002 Mar;53(4):1029-34. doi: 10.1016/s0008-6363(01)00534-x. PMID: 11922913.
 

168: Sinsheimer JS, McKenzie CA, Keavney B, Lange K. SNPs and snails and puppy dogs' tails: analysis of SNP haplotype data using the gamete competition model. Ann Hum Genet. 2001 Sep;65(Pt 5):483-90. doi: 10.1017/S0003480001008843. PMID: 11806856.
 

169: McKenzie CA, Abecasis GR, Keavney B, Forrester T, Ratcliffe PJ, Julier C, Connell JM, Bennett F, McFarlane-Anderson N, Lathrop GM, Cardon LR. Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE). Hum Mol Genet. 2001 May 1;10(10):1077-84. doi: 10.1093/hmg/10.10.1077. PMID: 11331618.
 

170: Keavney B, Watkins H. Evolution of genetic analysis strategies in coronary heart disease: a case of unnatural selection? Eur Heart J. 2001 Feb;22(4):271-3. doi: 10.1053/euhj.2000.2434. PMID: 11161941.
 

171: Winkelmann BR, Hager J, Kraus WE, Merlini P, Keavney B, Grant PJ, Muhlestein JB, Granger CB. Genetics of coronary heart disease: current knowledge and research principles. Am Heart J. 2000 Oct;140(4):S11-26. doi: 10.1067/mhj.2000.109636. PMID: 11011311.
 

172: Granger CB, Keavney B, Francomano C, Olsson G, Yusuf S. Recommendations for national and local regulatory authorities concerning research in genetic markers of disease. Am Heart J. 2000 Oct;140(4):S3-5. doi: 10.1067/mhj.2000.110350. PMID: 11011309.
 

173: Keavney B, Bird R, Caiazza A, Casadei B, Conway J. Measurement of blood pressure using the auscultatory and oscillometric methods in the same cuff deflation: validation and field trial of the A&D TM2421 monitor. J Hum Hypertens. 2000 Sep;14(9):573-9. doi: 10.1038/sj.jhh.1001100. PMID: 10980589.
 

174: Keavney B. Genetic association studies in complex diseases. J Hum Hypertens. 2000 Jun;14(6):361-7. doi: 10.1038/sj.jhh.1001020. PMID: 10878695.
 

175: Keavney B, McKenzie C, Parish S, Palmer A, Clark S, Youngman L, Delépine M, Lathrop M, Peto R, Collins R. Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators. Lancet. 2000 Feb 5;355(9202):434-42. doi: 10.1016/s0140-6736(00)82009-7. PMID: 10841123.
 

176: McKenzie CA, Keavney B, Forrester T, Julier C, Ratcliffe PJ. Screening for the GRA mutation in Jamaica. J Hum Hypertens. 2000 Feb;14(2):157-8. doi: 10.1038/sj.jhh.1000840. PMID: 10723126.
 

177: Farrall M, Keavney B, McKenzie C, Delépine M, Matsuda F, Lathrop GM. Fine- mapping of an ancestral recombination breakpoint in DCP1. Nat Genet. 1999 Nov;23(3):270-1. doi: 10.1038/15449. PMID: 10545941.
 

178: Keavney B, McKenzie CA, Connell JM, Julier C, Ratcliffe PJ, Sobel E, Lathrop M, Farrall M. Measured haplotype analysis of the angiotensin-I converting enzyme gene. Hum Mol Genet. 1998 Oct;7(11):1745-51. doi: 10.1093/hmg/7.11.1745. PMID: 9736776.
 

179: Brand E, Chatelain N, Keavney B, Caulfield M, Citterio L, Connell J, Grobbee D, Schmidt S, Schunkert H, Schuster H, Sharma AM, Soubrier F. Evaluation of the angiotensinogen locus in human essential hypertension: a European study. Hypertension. 1998 Mar;31(3):725-9. doi: 10.1161/01.hyp.31.3.725. PMID: 9495253.
 

180: Julier C, Delépine M, Keavney B, Terwilliger J, Davis S, Weeks DE, Bui T, Jeunemaître X, Velho G, Froguel P, Ratcliffe P, Corvol P, Soubrier F, Lathrop GM. Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. Hum Mol Genet. 1997 Nov;6(12):2077-85. doi: 10.1093/hmg/6.12.2077. PMID: 9328471.
 

181: Keavney B, Haider YM, McCance AJ, Skehan JD. Normal coronary angiograms: financial victory from the brink of clinical defeat? Heart. 1996 Jun;75(6):623-5. doi: 10.1136/hrt.75.6.623. PMID: 8697169; PMCID: PMC484389.
 

182: Dudley C, Keavney B, Casadei B, Conway J, Bird R, Ratcliffe P. Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes. J Hypertens. 1996 Feb;14(2):259-62. doi: 10.1097/00004872-199602000-00016. PMID: 8728305.
 

183: Dudley CR, Keavney B, Stratton IM, Turner RC, Ratcliffe PJ. U.K. Prospective Diabetes Study. XV: Relationship of renin-angiotensin system gene polymorphisms with microalbuminuria in NIDDM. Kidney Int. 1995 Dec;48(6):1907-11. doi: 10.1038/ki.1995.490. PMID: 8587251.
 

184: McKenzie CA, Julier C, Forrester T, McFarlane-Anderson N, Keavney B, Lathrop GM, Ratcliffe PJ, Farrall M. Segregation and linkage analysis of serum angiotensin I-converting enzyme levels: evidence for two quantitative-trait loci. Am J Hum Genet. 1995 Dec;57(6):1426-35. Erratum in: Am J Hum Genet 1996 Mar;58(3):648. PMID: 8533773; PMCID: PMC1801409.
 

185: Keavney B, McKenzie C. Coronary atherosclerosis and the angiotensinogen gene. Circulation. 1995 Oct 15;92(8):2356-7. PMID: 7554225.
 

186: Keavney BD, Dudley CR, Stratton IM, Holman RR, Matthews DR, Ratcliffe PJ, Turner RC. UK prospective diabetes study (UKPDS) 14: association of angiotensin- converting enzyme insertion/deletion polymorphism with myocardial infarction in NIDDM. Diabetologia. 1995 Aug;38(8):948-52. doi: 10.1007/BF00400584. PMID: 7589881.